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Role of BDNF in Central Motor Structures and Motor Diseases

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Abstract

Brain-derived neurotrophic factor (BDNF), belonging to the neurotrophic family of growth factors, has a widespread distribution in the central and peripheral nervous systems. In central motor structures including the motor cortex, cerebellum, basal ganglia, and spinal cord, BDNF exerts both neurotrophic and direct electrophysiological effects via a high-affinity tyrosine receptor kinase B receptor and a common low-affinity p75 neurotrophin receptor. The underlying signaling pathways mainly involve mitogen-activated protein kinase cascades, phosphatidylinositol 3-kinase pathway, and phospholipase C-γ pathway. The loss of BDNF usually leads to neurodegeneration in these motor centers and eventually results in several severe motor diseases, such as amyotrophic lateral sclerosis, spinocerebellar ataxias, Parkinson’s disease, Huntington’s disease, as well as vestibular syndrome. In this review, we summarize the recent understanding of functions of BDNF in motor structures and suggest that BDNF may be a potent candidate for the treatment of these neurodegenerative motor diseases.

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Acknowledgments

This work was supported by grants 31070959, 31071021, and 31171050 and the NSFC/RGC Joint Research Scheme 30931160433 from the National Natural Science Foundation of China; grant 2900336 from the Research Grants Council of Hong Kong, China; RFDP grant 20100091110016 and NCET Program from the State Educational Ministry of China; and grant BK2011014 from the Natural Science Foundation of Jiangsu Province, China.

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  1. Department of Biological Science and Technology and State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Mailbox 426, 22 Hankou Road, Nanjing, 210093, China

    Yan-Yan He, Xiao-Yang Zhang, Jing-Ning Zhu & Jian-Jun Wang

  2. School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China

    Wing-Ho Yung

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He, YY., Zhang, XY., Yung, WH. et al. Role of BDNF in Central Motor Structures and Motor Diseases. Mol Neurobiol 48, 783–793 (2013). https://doi.org/10.1007/s12035-013-8466-y

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