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Meta-analysis of the Association Between DCDC2 Polymorphisms and Risk of Dyslexia

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Abstract

Developmental dyslexia (DD) is a highly heritable neurological disorder that is prevalent in school-aged children. The dyslexia-associated gene DCDC2 is a member of the DCX family of genes known to play roles in neurogenesis, neuronal migration, and differentiation. However, the associations between DCDC2 genetic variations and dyslexia have yielded inconclusive results. Clarifying the effects of DCDC2 polymorphisms on dyslexia risk will advance not only elucidation of the role of DCDC2 in the brain development but also development of possible therapeutic approach for dyslexia. In this review, we summarized the ongoing association studies concerning DCDC2 polymorphisms and dyslexia risk by using meta-analysis and revealed that DCDC2 rs807701 might contribute significantly to dyslexia risk.

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Abbreviations

DD:

Developmental dyslexia

DCDC2 :

Doublecortin domain containing protein 2

TDT:

Transmission disequilibrium test

OR:

Odds ratio

CI:

Confidence interval

SNP:

Single nucleotide polymorphism

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Acknowledgments

This work is partially supported by the National Natural Science Foundation 81273092 to Ranran Song.

Conflicts of Interest

None.

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Authors and Affiliations

  1. Department of Epidemiology and Biostatistics, and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    Rong Zhong, Beifang Yang, Li Zou, Ranran Song & Xiaoping Miao

  2. Department of Pathophysiology, Key Lab of Neurological Diseases of Education Ministry, China-Canada Cooperation Platform of Neurological Disease, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    Rong Zhong, Hui Tang & Ling-Qiang Zhu

Authors
  1. Rong Zhong
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  2. Beifang Yang
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  3. Hui Tang
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  4. Li Zou
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  5. Ranran Song
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  6. Ling-Qiang Zhu
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  7. Xiaoping Miao
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Correspondence to Ling-Qiang Zhu or Xiaoping Miao.

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Zhong, R., Yang, B., Tang, H. et al. Meta-analysis of the Association Between DCDC2 Polymorphisms and Risk of Dyslexia. Mol Neurobiol 47, 435–442 (2013). https://doi.org/10.1007/s12035-012-8381-7

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  • DOI: https://doi.org/10.1007/s12035-012-8381-7

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