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Multifaceted Role of Heat Shock Protein 70 in Neurons

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Abstract

Heat shock protein 70 (Hsp70) plays important roles in neural protection from stress by assisting cellular protein folding. In this review we discuss the current understanding of inducible and constitutive Hsp70 in maintaining and protecting neuronal synaptic function under normal and stressed conditions.

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Aknowledgements

This work was supported by an operating grant to ZPF from the Canadian Institutes of Health Research (CIHR MOP62738). TZL is a recipient of Alexander Graham Bell Canadian Graduate Scholarship from Natural Sciences and Engineering Research Council of Canada (NSERC). ZPF holds a New Investigator Award from Heart and Stroke Foundation and a Young Investigator Award in Biological Sciences from Boehringer Ingelheim (Canada) Ltd.

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  1. Department of Physiology, University of Toronto, 3306 MSB, 1 King’s College Circle, Toronto, Ontario, Canada, M5S 1A8

    Tom Z. Lu, Yi Quan & Zhong-Ping Feng

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  1. Tom Z. Lu
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Correspondence to Zhong-Ping Feng.

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Tom Z. Lu and Yi Quan contributed equally to the manuscript.

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Lu, T.Z., Quan, Y. & Feng, ZP. Multifaceted Role of Heat Shock Protein 70 in Neurons. Mol Neurobiol 42, 114–123 (2010). https://doi.org/10.1007/s12035-010-8116-6

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