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Abnormal Mitochondrial Dynamics—A Novel Therapeutic Target for Alzheimer's Disease?

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Abstract

Mitochondria are dynamic organelles that undergo continuous fission and fusion, which could affect all aspects of mitochondrial function. Mitochondrial dysfunction has been well documented in Alzheimer’s disease (AD). In the past few years, emerging evidence indicates that an imbalance of mitochondrial dynamics is involved in the pathogenesis of AD. In this review, we discuss in detail the abnormal mitochondrial dynamics in AD and how such abnormal dynamics may impact mitochondrial and neuronal function and contribute to the course of disease. Based on this discussion, we propose that mitochondrial dynamics could be a potential therapeutic target for AD.

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Acknowledgement

This study is supported by the NIH (AG031852) and Alzheimer’s Association (IIRG-07-60196).

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Authors and Affiliations

  1. Department of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106, USA

    Bo Su, Xinglong Wang, David Bonda, Gorge Perry, Mark Smith & Xiongwei Zhu

  2. College of Sciences, University of Texas at San Antonio, San Antonio, TX, 78249, USA

    Gorge Perry

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  1. Bo Su
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  2. Xinglong Wang
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  3. David Bonda
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Correspondence to Xiongwei Zhu.

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Su, B., Wang, X., Bonda, D. et al. Abnormal Mitochondrial Dynamics—A Novel Therapeutic Target for Alzheimer's Disease?. Mol Neurobiol 41, 87–96 (2010). https://doi.org/10.1007/s12035-009-8095-7

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