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In-situ synthesized carboxymethyl chitosan/poly(vinyl alcohol) bio-nanocomposite hydrogels containing nanoparticles with drug-delivery properties

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Abstract

A drug-delivery approach was developed through effective preparation of bio-nanocomposite hydrogels in situ with ZnO/CuO/Ag nanoparticles being formed within swollen carboxymethyl chitosan (CMCh)/poly(vinyl alcohol) (PVA) hydrogels. Different experimental techniques, including Fourier transform-infrared, X-ray diffraction (XRD), energy-dispersive X-ray (EDX) analysis, and scanning electron microscopy (SEM) were applied to study and compare the prepared hydrogels. XRD and EDX analyses confirmed the formation of nanoparticles in the hydrogel matrix, while SEM micrographs showed that ZnO, CuO and Ag nanoparticles ranged from 36.26 to 76.09 nm, 34.15–71.71 nm and 36.21–78.47 nm within the same matrix, respectively. According to the results, an increased number of nanoparticles resulted from increased ion concentration. At pH 2.1 and pH 7.4, the bio-nanocomposite hydrogels were investigated in terms of the swelling behaviour; in comparison with neat CMCh/PVA hydrogel, they showed a pH-sensitive swelling ratio. As an in-vitro drug release test, the bio-nanocomposite hydrogels were applied to sustained and controlled drug-delivery system that increased with the increase in nanoparticles content that could result in protracted release of the ibuprofen.

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Acknowledgement

We acknowledge the Department of Chemistry, North Tehran Branch, Islamic Azad University for financial support of this work.

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Authors and Affiliations

  1. Department of Chemistry, North Tehran Branch, Islamic Azad University, P.O. Box 19585/936, Tehran, Iran

    Iman Gholamali, Manzarbanou Asnaashariisfahani & Eskandar Alipour

  2. Department of Microbiology, Faculty of Science, North Branch, Islamic Azad University, P.O. Box 19585/936, Tehran, Iran

    Abbas Akhavan Sepahi

Authors
  1. Iman Gholamali
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  2. Manzarbanou Asnaashariisfahani
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  3. Eskandar Alipour
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  4. Abbas Akhavan Sepahi
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Correspondence to Manzarbanou Asnaashariisfahani.

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Gholamali, I., Asnaashariisfahani, M., Alipour, E. et al. In-situ synthesized carboxymethyl chitosan/poly(vinyl alcohol) bio-nanocomposite hydrogels containing nanoparticles with drug-delivery properties. Bull Mater Sci 43, 264 (2020). https://doi.org/10.1007/s12034-020-02231-2

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  • DOI: https://doi.org/10.1007/s12034-020-02231-2

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