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Synthesis and characterization of SPIO-loaded PEG-b-PS micelles as contrast agent for long-term nanoparticle-based MRI phantom

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Abstract

Nanoparticle-based magnetic resonance imaging (MRI) phantom was developed from the suspension of magnetic nanoparticles composing methoxy poly(ethylene glycol)-block-poly(styrene) (PEG-b-PS) micelles and superparamagnetic iron oxide (SPIO) nanoparticles in the core of micelles. The size of SPIO-loaded micelles was determined by dynamic light scattering (DLS) and transmission electron microscopy. Larger-size micelles were found when SPIO loading was increased. The effect of the hydrophobic section of block copolymer on the size of micelles was studied by DLS. Transverse relaxivity was evaluated on both 1.5 and 3 T clinical MRI scanner. Higher SPIO-loading provided higher relaxivity, where the relaxivity of 10% SPIO-loaded PEG(5 kDa)-b-PS(5 kDa) were 144.0 and \(174.0~\hbox {m M}^{-1}~\hbox {s}^{-1}\) for 1.5 and 3 T MRI, respectively. This formulation showed stability over a 10-week period, and the standard deviations of the relaxivities were 3.0 and 8.0% for 1.5 and 3 T MRI, respectively. Thus, SPIO-loaded PEG-b-PS micelles have a potential to be applied as a contrast agent for nanoparticle-based MRI phantom.

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Acknowledgements

This research was supported by Mahidol University, Thailand.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, Phutthamonthon, Nakhon Pathom, 73170, Thailand

    Man Theerasilp & Norased Nasongkla

  2. Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand

    Man Theerasilp & Norased Nasongkla

  3. Department of Radiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand

    Witaya Sungkarat

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  1. Man Theerasilp
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  2. Witaya Sungkarat
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  3. Norased Nasongkla
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Correspondence to Norased Nasongkla.

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Theerasilp, M., Sungkarat, W. & Nasongkla, N. Synthesis and characterization of SPIO-loaded PEG-b-PS micelles as contrast agent for long-term nanoparticle-based MRI phantom. Bull Mater Sci 41, 42 (2018). https://doi.org/10.1007/s12034-018-1556-8

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  • DOI: https://doi.org/10.1007/s12034-018-1556-8

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