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Human Protein Reference Database and Human Proteinpedia as Discovery Resources for Molecular Biotechnology

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Abstract

In the recent years, research in molecular biotechnology has transformed from being small scale studies targeted at a single or a small set of molecule(s) into a combination of high throughput discovery platforms and extensive validations. Such a discovery platform provided an unbiased approach which resulted in the identification of several novel genetic and protein biomarkers. High throughput nature of these investigations coupled with higher sensitivity and specificity of Next Generation technologies provided qualitatively and quantitatively richer biological data. These developments have also revolutionized biological research and speed of data generation. However, it is becoming difficult for individual investigators to directly benefit from this data because they are not easily accessible. Data resources became necessary to assimilate, store and disseminate information that could allow future discoveries. We have developed two resources—Human Protein Reference Database (HPRD) and Human Proteinpedia, which integrate knowledge relevant to human proteins. A number of protein features including protein–protein interactions, post-translational modifications, subcellular localization, and tissue expression, which have been studied using different strategies were incorporated in these databases. Human Proteinpedia also provides a portal for community participation to annotate and share proteomic data and uses HPRD as the scaffold for data processing. Proteomic investigators can even share unpublished data in Human Proteinpedia, which provides a meaningful platform for data sharing. As proteomic information reflects a direct view of cellular systems, proteomics is expected to complement other areas of biology such as genomics, transcriptomics, molecular biology, cloning, and classical genetics in understanding the relationships among multiple facets of biological systems.

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Authors and Affiliations

  1. Institute of Bioinformatics, International Technology Park, Bangalore, 560 066, India

    Renu Goel, Babylakshmi Muthusamy & T. S. Keshava Prasad

  2. Department of Biotechnology, Kuvempu University, Shankaraghatta, 577 451, Karnataka, India

    Renu Goel

  3. Bioinformatics Centre, School of Life Sciences, Pondicherry University, Pondicherry, 605 014, India

    Babylakshmi Muthusamy & T. S. Keshava Prasad

  4. McKusick-Nathans Institute of Genetic Medicine and Departments of Biological Chemistry, Pathology and Oncology, Johns Hopkins University, Baltimore, MD, 21205, USA

    Akhilesh Pandey

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  1. Renu Goel
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  2. Babylakshmi Muthusamy
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  3. Akhilesh Pandey
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  4. T. S. Keshava Prasad
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Correspondence to Akhilesh Pandey or T. S. Keshava Prasad.

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Goel, R., Muthusamy, B., Pandey, A. et al. Human Protein Reference Database and Human Proteinpedia as Discovery Resources for Molecular Biotechnology. Mol Biotechnol 48, 87–95 (2011). https://doi.org/10.1007/s12033-010-9336-8

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