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Notch signaling pathway networks in cancer metastasis: a new target for cancer therapy

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Abstract

Notch signaling pathway is evolutionarily conserved in mammals, which plays an important role in cell development and differentiation. In recent years, increasing evidence has shown that aberrant activation of Notch is associated with tumor process. Aberrant activation of Notch signaling pathway has been found in many different solid tumors can induce cell proliferation, metastasis and epithelial-mesenchymal transition. Notch receptor and its ligand are both single transmembrane protein, and Notch is activated when it binds to the Notch ligand of neighbor cells. The signal transduction of Notch signaling pathway is only between cells that are in contact with each other, which is independent of second messengers. Thus, Notch needs to cross talk with other signaling pathways, including PI3K/AKT, NF-κB, integrin and miRNAs, to precisely regulate cell fate. In this review, we summarize the roles of Notch signaling pathway in tumor metastasis and its regulatory mechanisms and discuss the current treatment strategies targeting Notch signal pathway.

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Acknowledgements

We would like to thank the National Natural Science Foundation of China (11772088, 31470906, 31700811, 11502049, 81671821, 31470959, 81471785), the Basic Research Program of Sichuan Science and Technology (2017JY0019, 2017JY0217), the China Postdoctoral Science Foundation (2016M592657), the Fundamental Research Funds for the Central Universities (ZYGX2016Z001, ZYGX2015J143) and the Postdoctoral Science Foundation of University of Electronic Science and Technology of China (Y0200623601737) for financial support.

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Authors and Affiliations

  1. Department of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, Sichuan, People’s Republic of China

    Li Li, Shun Li, Xiang Qin, Hong Yang, Chunhui Wu & Yiyao Liu

  2. Center for Information in Biology, University of Electronic Science and Technology of China, Chengdu, 610054, Sichuan, People’s Republic of China

    Li Li, Shun Li, Xiang Qin, Hong Yang, Chunhui Wu & Yiyao Liu

  3. Department of Physiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, 610041, Sichuan, People’s Republic of China

    Ping Tang

  4. Neuroscience and Metabolism Research, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People’s Republic of China

    Ping Tang

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  1. Li Li
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  2. Ping Tang
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  3. Shun Li
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Correspondence to Yiyao Liu.

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Li, L., Tang, P., Li, S. et al. Notch signaling pathway networks in cancer metastasis: a new target for cancer therapy. Med Oncol 34, 180 (2017). https://doi.org/10.1007/s12032-017-1039-6

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