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OSNA (one-step nucleic acid amplification) sentinel lymph node intraoperative molecular analysis in breast cancer: a cost-benefit analysis

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Abstract

The aim of the study was to analyze the medical and economic interest of OSNA molecular technique, compared to conventional postoperative histopathologic evaluation for sentinel lymph node exploration in breast cancer patients. This retrospective cost-benefit study was conducted in the French Universitary Hospital of Saint Etienne on patients who received sentinel lymph node exploration between July 1, 2007 and December 31, 2009. Lymph nodes were analyzed by conventional postoperative histological evaluation in group 1 (82 patients) and OSNA in group 2 (86 patients). Costs were analyzed in three different ways: surgery cost, hospitalization cost and histopathologic cost. Average operating time was slightly shorter for group 1 (histology) [71.9 vs. 76.8 min for group 2 (OSNA)]. Time and operating costs were not significantly different (p = 0.293). The average cost of pathological examination was significantly higher in group 2 (35.04 euros per node in group 1 vs. 291.84 euros per node in group 2 p < 10−3). The average length of hospital stay was significantly longer in group 1 (5.4 days in group 1 vs. 4.2 days in group 2, p = 0.0065). The total costs were not significantly different between both groups (3,774.6 euros in group 1 vs. 3,393.9 euros in group 2 p = 0.055). The sentinel lymph node analysis with OSNA technique does not lead to higher expenses. It also avoids another surgery for 20 % of patients. A prospective multicentric medico-economic study made with a larger effective would probably confirm these results.

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Authors and Affiliations

  1. Department of Gynecological and Oncological Surgery, University Medical Center, Saint Etienne, France

    Tiphaine Raia-Barjat, Pierre Seffert & Céline Chauleur

  2. Department of Public Health, University Medical Center, Saint Etienne, France

    Béatrice Trombert & Céline Chauleur

  3. Department of Pathology, University Medical Center, Saint Etienne, France

    Béatrice Trombert, Abir Khaddage, Catherine Douchet, Michel Peoc’h & Céline Chauleur

  4. Department of Radiotherapy, Centre Antoine Lacassagne, Nice, France

    Béatrice Trombert & Céline Chauleur

  5. Département de Radiothérapie, Institut de cancérologie de la Loire – Lucien Neuwirth, 108 bis, Avenue Albert Raimond, BP 60008, 42271, Saint-Priest en Jarez, France

    Béatrice Trombert, Nicolas Magné & Céline Chauleur

  6. EA-SNA-EPIS, Saint Etienne, France

    Béatrice Trombert & Céline Chauleur

  7. EA3065 Group of Search on Thrombosis, Saint Etienne, France

    Céline Chauleur

  8. Department of Radiation Oncology, Centre Antoine Lacassagne, 33 Avenue Valombrose, 06000, Nice, France

    Alexander Tuan Falk

Authors
  1. Tiphaine Raia-Barjat
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  2. Béatrice Trombert
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  3. Abir Khaddage
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  4. Catherine Douchet
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  5. Pierre Seffert
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  6. Michel Peoc’h
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  7. Alexander Tuan Falk
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  8. Nicolas Magné
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  9. Céline Chauleur
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Correspondence to Alexander Tuan Falk.

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Raia-Barjat, T., Trombert, B., Khaddage, A. et al. OSNA (one-step nucleic acid amplification) sentinel lymph node intraoperative molecular analysis in breast cancer: a cost-benefit analysis. Med Oncol 31, 322 (2014). https://doi.org/10.1007/s12032-014-0322-z

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  • DOI: https://doi.org/10.1007/s12032-014-0322-z

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