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Association between XRCC1 polymorphisms and glioma risk among Chinese population

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Abstract

The pathogenesis of glioma remains largely unknown now. It has been suggested that the X-ray cross-complementing group 1 (XRCC1) gene may influence the capacity to repair DNA damage leading to an increased gliomas susceptibility. This study aimed to evaluate the relationship between XRCC1 polymorphisms and glioma risk. Genotypes were assessed in 368 Chinese glioma patients and 346 healthy controls. XRCC1 Arg194Trp (rs1799782), Arg280His (rs25489) and Arg399Gln (rs25487) and three additional polymorphisms were directly sequenced. The frequency of Arg280His A allele was significant lower in glioma group than in healthy controls [9.6 vs 16 %, OR = 0.60 (0.46–0.80), P < 0.001]; the frequencies of GA or AA genotypes were different in two groups (16.6 vs 22.8 %, 1.3 vs 4.7 %). The frequency of Arg399Gln A allele was significant higher in glioma group than in healthy controls [38.7 vs 30.1 %, OR = 1.29 (1.11–1.49), P = 0.001]; the frequencies of GA or AA genotypes were different in two groups (45.4 vs 38.2 %, 16 vs 10.9 %). This study demonstrates that the rs25489 (Arg280His) and Arg399Gln (rs25487) polymorphisms in XRCC1 gene might influence the risk of developing glioma in Chinese population.

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Acknowledgments

We thank the study participants and supported grants of the Research Innovation Foundation of Graduate Student in Hunan Province, P.R.C (CX2011B056) and Hunan Provincial Innovation Foundation for Postgraduate (CX2013B102).

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Clinical Laboratory, Hunan Provincial People’s Hospital, Changsha, 410005, People’s Republic of China

    Jiang Li

  2. Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, 410078, People’s Republic of China

    Qiang Qu

  3. Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410078, People’s Republic of China

    Jian Qu

  4. Department of Spinal Surgery, Changsha Central Hospital, Changsha, Hunan, 410004, People’s Republic of China

    Wei-Ming Luo, Shang-Yuan Wang, You-Zhi He, Qi-Shan Luo, Yu-Xia Xu & Yong-Fu Wang

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  1. Jiang Li
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Correspondence to Yong-Fu Wang.

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Cite this article

Li, J., Qu, Q., Qu, J. et al. Association between XRCC1 polymorphisms and glioma risk among Chinese population. Med Oncol 31, 186 (2014). https://doi.org/10.1007/s12032-014-0186-2

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  • DOI: https://doi.org/10.1007/s12032-014-0186-2

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