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Low expression of long noncoding RNA GAS6-AS1 predicts a poor prognosis in patients with NSCLC

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Abstract

Lung cancer is the most frequent cancer in China and all over the world. Recent studies have shown that long noncoding RNAs play critical roles in multiple biological processes including oncogenesis. In this study, we reported a new lncRNA GAS6-AS1 (GAS6 antisense RNA 1), whose expression was downregulated in tumor tissues in 50 patients with non-small cell lung cancer (NSCLC) compared with those in the adjacent normal tissues (P < 0.001). Furthermore, decreased GAS6-AS1 expression was negatively correlated with lymph node metastasis (P = 0.032) and advanced tumor node metastasis stage (P = 0.003). Univariate and multivariate analyses showed that GAS6-AS1 expression served as an independent predictor for overall survival (P = 0.036). Also, GAS6-AS1 level was inversely correlated with GAS6 (growth-arrest-specific gene6) mRNA level (Pearson’s correlation −0.620). In conclusion, our study demonstrated that altered lncRNA GAS6-AS1 expression might be involved in the development and progression of NSCLC by influencing its host gene and promised to be a potential diagnostic target in patients with NSCLC.

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Authors and Affiliations

  1. Department of Oncology, Xuzhou Central Hospital, Affiliated Xuzhou Hospital, College of Medicine, Southeast University, Xuzhou, 221000, Jiangsu, China

    Liang Han

  2. Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, Jiangsu, China

    Rong Kong, Er-Bao Zhang & Wei De

  3. Central Laboratory, The Second Affiliated Hospital of Southeast University, Nanjing, China

    Dan-Dan Yin

  4. Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

    Tong-Peng Xu & Yong-Qian Shu

Authors
  1. Liang Han
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  2. Rong Kong
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  3. Dan-Dan Yin
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  4. Er-Bao Zhang
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  5. Tong-Peng Xu
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  6. Wei De
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  7. Yong-Qian Shu
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Corresponding author

Correspondence to Yong-Qian Shu.

Additional information

Liang Han, Rong Kong and Dan-dan Yin contributed equally to this work and should be regarded as joint first authors.

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Han, L., Kong, R., Yin, DD. et al. Low expression of long noncoding RNA GAS6-AS1 predicts a poor prognosis in patients with NSCLC. Med Oncol 30, 694 (2013). https://doi.org/10.1007/s12032-013-0694-5

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  • DOI: https://doi.org/10.1007/s12032-013-0694-5

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