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Overexpression of TFIIB-related factor 2 is significantly correlated with tumor angiogenesis and poor survival in patients with esophageal squamous cell cancer

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Abstract

Studies have shown that genetic activation of TFIIB-related factor 2 (BRF2) represents a unique mechanism of tumorigenesis through the increase in Pol III-mediated transcription. Several studies have shown that BRF2 is overexpressed in several types of cancer and suggest the oncogenic role of BRF2. This study aimed to examine the expression of TFIIB-related factor 2 (BRF2) in patients with esophageal squamous cell cancer (ESCC) and explore the relationship of BRF2 expression with clinicopathologic factors, tumor angiogenesis and prognosis. We found that increased BRF2 protein expression was prevalent in esophageal squamous cell cancer and was significantly associated with deeper tumor invasion (P = 0.039) and microvessel density (P = 0.007). Additionally, expression of BRF2 was found to be an independent prognostic factor in ESCC patients. Furthermore, a significant correlation between high BRF2 expression and shorter overall survival time was found in different subgroups of ESCC patients stratified by the clinical stage, T classification and lymph node metastasis. High expression of BRF2 protein is closely associated with tumor progression and angiogenesis and poor survival of ESCC. BRF2 is a promising biomarker to identify individuals with poor prognostic potential and concludes the possibility of its use as a prognostic marker in patients with ESCC.

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Acknowledgments

The authors are grateful to Guangzhen Li (Department of General Surgery) for his data analysis from Qilu Hospital, Shandong University, China. This project was supported by the National Natural Science Foundation of China (No. 30571844), and the Science and Technology Development Foundation of Shandong Province (No. 2009GG10002007), and the National Natural Science Foundation of Shandong Province (No. ZR2009CM090). Sponsors had no involvement in the study design; in the collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication.

Conflict of interest

All authors have read and approved this statement and have no financial and personal relationships with other people or organizations that could be inappropriate to this work.

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Authors and Affiliations

  1. Department of Thoracic Surgery, Qilu Hospital, Shandong University, 44# Wenhua Xi Road, Jinan, 250012, People’s Republic of China

    Ming Lu, Hui Tian, Weiming Yue, Lin Li, Shuhai Li, Lei Qi, Wensi Hu, Cun Gao & Libo Si

  2. Department of Thoracic Surgery, Qilu Hospital, Shandong University, 107# Wenhua Xi Road, Jinan, 250012, People’s Republic of China

    Ming Lu, Hui Tian, Weiming Yue, Lin Li, Shuhai Li, Lei Qi, Wensi Hu, Cun Gao & Libo Si

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  1. Ming Lu
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Correspondence to Hui Tian.

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Lu, M., Tian, H., Yue, W. et al. Overexpression of TFIIB-related factor 2 is significantly correlated with tumor angiogenesis and poor survival in patients with esophageal squamous cell cancer. Med Oncol 30, 553 (2013). https://doi.org/10.1007/s12032-013-0553-4

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  • DOI: https://doi.org/10.1007/s12032-013-0553-4

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