Abstract
This study was to investigate the association of inflammation-related factors with the risk of lung cancer. All subjects were unrelated ethnic Han Chinese in Liaoning province. Our study conducted a hospital-based case–control study, the case group consisted of 193 histologically diagnosed lung cancer patients, and 211 controls were selected from cancer-free patients at the same. 5 single-nucleotide polymorphisms (TGFβ1 +869T/C, IL6 −634C/G, TGFβ1 −509C/T, IL1β −511C/T, and IL1α −899C/T) in inflammatory genes (IL1, IL6, TGF) were analyzed by Taqman real-time PCR method. All statistical analyses were performed with statistical product and service solutions v13.0. The genotype distribution frequency of IL6 −634C/G exists significant difference between case and control group. Individuals carrying −634GG and CG genotype had a higher risk of lung cancer. The risk allele was G in IL6 −634C/G.
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The grant of scientific and technological breakthroughs project (Shenyang City, P. R. China, No. 1091149-9-00). The grant of science and technology project (Liaoning Province, P. R. China, No.2011225019).
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Bai, L., Yu, H., Wang, H. et al. Genetic single-nucleotide polymorphisms of inflammation-related factors associated with risk of lung cancer. Med Oncol 30, 414 (2013). https://doi.org/10.1007/s12032-012-0414-6
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DOI: https://doi.org/10.1007/s12032-012-0414-6