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Polymorphism of VEGF−460C/T associated with the risk and clinical characteristics of lung cancer in Chinese population

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Abstract

Vascular endothelial growth factor (VEGF) is a major regulator of angiogenesis in the process of tumor growth and metastasis. Different VEGF gene polymorphisms have been shown to result in different VEGF protein expression in cancer cells and tumor angiogenic activity. We conducted a case–control study to evaluate the genetic effects of VEGF−460C/T polymorphism on the development of lung cancer. One hundred and twenty-six lung cancer patients and 160 sex-, age-, and ethnic-matched healthy controls were recruited for this study. The genotypes were determined by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP). Odds ratios (ORs) and 95 % confidence intervals (CI) were calculated by logistic regression analysis. Our study showed that the TT genotype was associated with increased lung cancer risk than those with the CC (OR = 1.99, 95 % CI 1.05–3.77) or CT/CC (OR = 1.89, 95 % CI 1.17–3.06) genotype. Moreover, it was observed that the TT genotype associated with the advanced stage among lung cancer patients (TT vs. CC: OR = 3.09, 95 % CI 1.10–8.66). More studies are needed to detect VEGF−460C/T polymorphism and its association with lung cancer in different ethnic populations incorporated with environmental exposures.

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References

  1. McMahon G. VEGF receptor signaling in tumor angiogenesis. Oncologist. 2000;5(Suppl 1):3–10.

    Article  PubMed  CAS  Google Scholar 

  2. Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev. 1997;18:4–25.

    Article  PubMed  CAS  Google Scholar 

  3. Ferrara N. VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer. 2002;2:795–803.

    Article  PubMed  CAS  Google Scholar 

  4. Vincenti V, Cassano C, Rocchi M, Persico G. Assignment of the vascular endothelial growth factor gene to human chromosome 6p21.3. Circulation. 1996;93:1493–5.

    Article  PubMed  CAS  Google Scholar 

  5. Chae YS, et al. Association of vascular endothelial growth factor gene polymorphisms with susceptibility and clinicopathologic characteristics of colorectal cancer. J Korean Med Sci. 2008;23:421–7.

    Article  PubMed  CAS  Google Scholar 

  6. Gerger A, et al. Pharmacogenetic angiogenesis profiling for first-line bevacizumab plus oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer. Clin Cancer Res. 2011;17:5783–92.

    Article  PubMed  CAS  Google Scholar 

  7. Lee SJ, et al. Vascular endothelial growth factor gene polymorphisms and risk of primary lung cancer. Cancer Epidemiol Biomarkers Prev. 2005;14:571–5.

    Article  PubMed  CAS  Google Scholar 

  8. Zhai R, et al. Vascular endothelial growth factor genotypes, haplotypes, gender, and the risk of non-small cell lung cancer. Clin Cancer Res. 2008;14:612–7.

    Article  PubMed  CAS  Google Scholar 

  9. Cao C, et al. Vascular endothelial growth factor +936C/T and +405G/C polymorphisms and cancer risk: a meta-analysis. Arch Med Res. 2010;41:548–57.

    Article  PubMed  CAS  Google Scholar 

  10. Cao C, et al. Polymorphism of vascular endothelial growth factor -2578C/A with cancer risk: evidence from 11263 subjects. Med Oncol. 2011;28:1169–75.

    Article  PubMed  CAS  Google Scholar 

  11. Xu B, et al. VEGF −460C>T polymorphism and cancer risk: a meta-analysis. Med Oncol. 2010;27:1031–6.

    Article  PubMed  CAS  Google Scholar 

  12. Chae YS, et al. Investigation of vascular endothelial growth factor gene polymorphisms and its association with clinicopathologic characteristics in gastric cancer. Oncology. 2006;71:266–72.

    Article  PubMed  CAS  Google Scholar 

  13. Koukourakis MI, et al. VEGF gene sequence variation defines VEGF gene expression status and angiogenic activity in non-small cell lung cancer. Lung Cancer. 2004;46:293–8.

    Article  PubMed  Google Scholar 

  14. Sfar S, Hassen E, Saad H, Mosbah F, Chouchane L. Association of VEGF genetic polymorphisms with prostate carcinoma risk and clinical outcome. Cytokine. 2006;35:21–8.

    Article  PubMed  CAS  Google Scholar 

  15. Ding QL, Sun SF, Cao C, Deng ZC. Association between angiotensin-converting enzyme I/D polymorphism and asthma risk: a meta-analysis involving 11,897 subjects. J Asthma. 2012;49:557–62.

    Article  PubMed  CAS  Google Scholar 

  16. Tahara T, et al. Effect of polymorphisms in the 3′ untranslated region (3′-UTR) of vascular endothelial growth factor gene on gastric cancer and peptic ulcer diseases in Japan. Mol Carcinog. 2009;48:1030–7.

    Article  PubMed  CAS  Google Scholar 

  17. Langsenlehner T, et al. Impact of VEGF gene polymorphisms and haplotypes on radiation-induced late toxicity in prostate cancer patients. Strahlenther Onkol. 2011;187:784–91.

    Article  PubMed  Google Scholar 

  18. Galimberti S, et al. Vascular endothelial growth factor polymorphisms in mantle cell lymphoma. Acta Haematol. 2010;123:91–5.

    Article  PubMed  CAS  Google Scholar 

  19. Hsieh YY, Chang CC, Tsai FJ, Lin CC, Tsai CH. T allele for VEGF-460 gene polymorphism at 5′-untranslated region is associated with higher susceptibility of leiomyoma. Biochem Genet. 2008;46:356–61.

    Article  PubMed  CAS  Google Scholar 

  20. Lin CC, Wu HC, Tsai FJ, Chen HY, Chen WC. Vascular endothelial growth factor gene-460 C/T polymorphism is a biomarker for prostate cancer. Urology. 2003;62:374–7.

    Article  PubMed  Google Scholar 

  21. Zhao Z, Ba C, Wang W, Wang X, Xue R, Wu X. Vascular endothelial growth factor (VEGF) gene polymorphisms and colorectal cancer: a meta-analysis of epidemiologic studies. Genet Test Mol Biomarkers. 2012;16:1390–4.

    Article  PubMed  CAS  Google Scholar 

  22. Bae SJ, et al. Gender-specific association between polymorphism of vascular endothelial growth factor (VEGF 936C>T) gene and patients with stomach cancer. Yonsei Med J. 2008;49:783–91.

    Article  PubMed  CAS  Google Scholar 

  23. Eroğlu A, Oztürk A, Cam R, Akar N. Vascular endothelial growth factor gene 936 C/T polymorphism in breast cancer patients. Med Oncol. 2008;25:54–5.

    Article  PubMed  Google Scholar 

  24. Sfar S, Saad H, Mosbah F, Chouchane L. Combined effects of the angiogenic genes polymorphisms on prostate cancer susceptibility and aggressiveness. Mol Biol Rep. 2009;36:37–45.

    Article  PubMed  CAS  Google Scholar 

  25. Salajegheh A, et al. Single nucleotide polymorphisms and mRNA expression of VEGF-A in papillary thyroid carcinoma: potential markers for aggressive phenotypes. Eur J Surg Oncol. 2011;37:93–9.

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

This work was supported by the grant of Social Development Scientific Research Project of Ningbo (No.2011C50025, C Cao) and grant of Natural Science Foundation of Ningbo (No.2012A610257, ZC Deng).

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None declared.

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Authors and Affiliations

  1. Department of Respiratory Medicine, Affiliated Hospital, Medical College, Ningbo University, Ningbo, 315020, China

    Shi-Fang Sun, Chao Cao & Zai-Chun Deng

  2. Department of Oncology, Anhui Provincial Hospital, Anhui Medical University, Hefei, 230001, China

    Da-Bing Huang

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  1. Shi-Fang Sun
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  2. Da-Bing Huang
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  3. Chao Cao
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  4. Zai-Chun Deng
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Correspondence to Zai-Chun Deng.

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Sun, SF., Huang, DB., Cao, C. et al. Polymorphism of VEGF−460C/T associated with the risk and clinical characteristics of lung cancer in Chinese population. Med Oncol 30, 410 (2013). https://doi.org/10.1007/s12032-012-0410-x

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  • DOI: https://doi.org/10.1007/s12032-012-0410-x

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