Skip to main content

Advertisement

Log in

A coincidence of renal cell carcinoma and hematological malignancies

  • Letter to the Editor
  • Published:
Medical Oncology Aims and scope Submit manuscript

Abstract

Hematological malignancies with renal cell carcinoma (RCC) are rarely seen. We reported here two cases of coincidence of RCC with multiple myeloma (MM) and Hodgkin’s disease (HD). A 69-year-old male patient with tumor that was located at the upper pole of left kidney was admitted to our clinic. Partial tumoral resection was perfomed and stage-I RCC was diagnosed after the histopathological examination of tumor. Moreover, he was diagnosed with IgG kappa stage-IIA MM as a result of bone marrow examination and serum immunofixation electrophoresis. Radiotherapy, combination chemotherapy, and autologous stem cell transplantation (ASCT) were performed. The patient is still alive who achieve a complete remission. A 53-year-old male patient suffered from cervival lymphadenopathy. He has a story of right radical nefrectomy that has been performed 4 years ago. Stage II-B lymphocyte-predominant HD was diagnosed. Combination chemotherapy was started, but relapse occurred 25 months later. ASCT was not planned due to cardiovascular problems and the patient died. Clinicans should keep in mind the coincidence of RCC with MM and HD.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Beisland C, Talleraas O, Bakke A, et al. Multiple primary malignancies in patients with renal cell carcinoma: a national population-based cohort study. BJU Int. 2006;97:698–702.

    Article  PubMed  Google Scholar 

  2. Howlader N, Noone AM, Krapcho M, Neyman N, Aminou R, Altekruse SF, Kosary CL, Ruhl J, Tatalovich Z, Cho H, Mariotto A, Eisner MP, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER cancer statistics review, 1975–2009 (Vintage 2009 Populations), National Cancer Institute. Bethesda, MD. http://seer.cancer.gov/csr/1975_2009_pops09/. Based on November 2011 SEER data submission, posted to the SEER web site, 2012.

  3. Rodriguez MA, Fuller LM, Zimmerman SO. Hodgkin’s disease: study of treatment intensities and incidences of second malignancies. Ann Oncol. 1993;4:125–31.

    PubMed  CAS  Google Scholar 

  4. Valagussa P. Second neoplasms following treatment of Hodgkin’s disease. Curr Opin Oncol. 1993;5:805–11.

    Article  PubMed  CAS  Google Scholar 

  5. Tihan T, Filippa DA. Coexistence of renal cell carcinoma and malignant lymphoma: a causal relationship or coincidental occurrence? Cancer. 1996;77:2325.

    Article  PubMed  CAS  Google Scholar 

  6. Nishikubo CY, Kunkei LA, Figlin R. An association between renal cell carcinoma and lymphoid malignancies. Cancer. 1996;78:2421–6.

    Article  PubMed  CAS  Google Scholar 

  7. Rabbani F, Grimaldi G, Russo P. Multiple primary malignancies in renal cell carcinoma. J Urol. 1998;160:1255–9.

    Google Scholar 

  8. Rabbani F, Russo P. Lack of association between renal cell carcinoma and non-Hodgkin’s lymphoma. Urology. 1999;54:28–33.

    Article  PubMed  CAS  Google Scholar 

  9. Shah IA, Haddad FS, Gani OS, et al. An association between renal cell carcinoma and lymphoid malignancies: a case series of eight patients. Cancer. 1997;80:1005–7.

    Article  PubMed  CAS  Google Scholar 

  10. Anderson CM, Pusztai L, Palmer JL, et al. Coincident renal cell carcinoma and nonHodgkin’s lymphoma: the M.D. Anderson experience and review of the literature. J Urol. 1998;159:714–7.

    Article  PubMed  CAS  Google Scholar 

  11. Kunthur A, Wiernik PH, Dutcher JP. Renal parenchymal tumors and lymphoma in the same patient: case series and review of the literature. Am J Hematol. 2006;81:271–80.

    Article  PubMed  Google Scholar 

  12. Shah SA, Ormerod AD, Husain A, et al. Primary cutaneous CD30 (Ki-1)-positive anaplastic large cell lymphoma associated with renal cell carcinoma. Br J Dermatol. 1999;140:971–2.

    Article  PubMed  CAS  Google Scholar 

  13. Ohsawa M, Hashimoto M, Yasunaga Y, et al. Characteristics of non-Hodgkin’s lymphoma complicated by renal cell malignancies. Oncology. 1998;55:482–6.

    Article  PubMed  CAS  Google Scholar 

  14. Wang BY, Strauchen JA, Rabinowitz D, Tillem SM, Unger PD. Renal cell carcinoma with intravascular lymphomatosis: a case report of unusual collision tumors with review of the literature. Arch Pathol Lab Med. 2001;125:1239–41.

    PubMed  CAS  Google Scholar 

  15. Yagisawa K, Ohno Y, Toba K, et al. Three cases of malignant lymphoma accompanied by renal cell carcinoma. Rinsho Ketsueki. 2001;42:616–20.

    PubMed  CAS  Google Scholar 

  16. Victor H, Jimenez I. Coexistence between renal cell cancer and Hodgkin’s lymphoma: a rare coincidence. BMC Urol. 2006;6:10.

    Article  Google Scholar 

  17. Choueiri TK, Baz RC, McFadden CM, et al. An association between renal cell carcinoma and multiple myeloma: a case series and clinical implications. BJU Int. 2007;101:712–5.

    Article  PubMed  Google Scholar 

  18. Ojha RP, Evans EL, Felini MJ, et al. The association between renal cell carcinoma and multiple myeloma: ınsights from population-based data. BJU Int. 2010;108:825–30.

    PubMed  Google Scholar 

  19. Ozturk MA, Dane F, Kaygusuz I, et al. Synchronous renal cell carcinoma and multiple myeloma: report of two cases and review of the literature. J Buon. 2009;14:511–4.

    PubMed  CAS  Google Scholar 

  20. Sakai A, Kawano M, Kuramoto A. Interleukin-6 produced by renal-cell carcinoma cells and progression of multiple myeloma. N Engl J Med. 1991;324:1893–4.

    Article  PubMed  CAS  Google Scholar 

  21. Renehan AG, Tyson M, Egger M, et al. Body-mass index and incidence of cancer: a systematic review and metaanalysis of prospective observational studies. Lancet. 2008;371:569–78.

    Article  PubMed  Google Scholar 

Download references

Conflict on interest

We have not conflict of interest.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Gokhan Sargın.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sargın, G., Yavasoglu, I., Doger, F.K. et al. A coincidence of renal cell carcinoma and hematological malignancies. Med Oncol 29, 3335–3338 (2012). https://doi.org/10.1007/s12032-012-0316-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12032-012-0316-7

Keywords

Navigation