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Extraperitoneal response to intraperitoneal immunotherapy with catumaxomab in a patient with cutaneous lymphangiosis carcinomatosa from ovarian cancer: a case report and review of the literature

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Abstract

Cutaneous metastasation is a very rare manifestation of ovarian cancer. We present the case of a 64-year-old woman with recurrent platinum-refractory ovarian cancer and skin metastasis. The patient was treated with intraperitoneal catumaxomab due to massive refractory malignant ascites. Clinical response of the skin metastasis was observed during the intraperitoneal treatment with catumaxomab. Even though response of extraperitoneal tumor sites can be explained with intravascular uptake and a possible vaccination effect, this phenomenon has not been reported up to this point to the best of our knowledge.

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Authors and Affiliations

  1. Department of Gynecology, European Competence Center for Ovarian Cancer, Charité-Campus Virchow Klinikum, Medical University of Berlin, Augustenburger Platz 1, 13353, Berlin, Germany

    H. Woopen, K. Pietzner, G. Oskay-Oezcelik & J. Sehouli

  2. Institute of Pathology, Charité-Campus Mitte, Medical University of Berlin, Charité Platz 1, 10117, Berlin, Germany

    S. Darb-Esfahani

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  1. H. Woopen
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  2. K. Pietzner
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  3. S. Darb-Esfahani
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  4. G. Oskay-Oezcelik
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  5. J. Sehouli
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Correspondence to K. Pietzner.

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Woopen, H., Pietzner, K., Darb-Esfahani, S. et al. Extraperitoneal response to intraperitoneal immunotherapy with catumaxomab in a patient with cutaneous lymphangiosis carcinomatosa from ovarian cancer: a case report and review of the literature. Med Oncol 29, 3416–3420 (2012). https://doi.org/10.1007/s12032-012-0285-x

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  • DOI: https://doi.org/10.1007/s12032-012-0285-x

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