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Expression and clinical significance of GRIM-19 in lung cancer

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Abstract

We investigated the expression of gene associated with retinoid-interferon-induced mortality-19 (GRIM-19) in lung cancer, a recently discovered cell death regulatory gene. Over-expression of GRIM-19 potentially suppresses proliferation and promotes tumor cell apoptosis. However, the expression of GRIM-19 in human lung cancer has not yet been thoroughly investigated. All of the specimens were obtained using CT-guided lung puncture or bronchial biopsy. The expression of GRIM-19 was investigated using immunohistochemistry. The expression level of GRIM-19 was significantly different between lung cancer and lung inflammation. A relatively lower GRIM-19 expression level was also found in small cell lung carcinomas compared to squamous cell carcinoma and adenocarcinoma. No significant difference between GRIM-19 expression in squamous cell carcinoma and adenocarcinoma was determined. Downregulation of GRIM-19 was found in non-small cell lung carcinomas stages III–IV compared to stages I–II, indicating a negative correlation between the expression level of GRIM-19 and the stage of the primary lesion (T). Furthermore, we found GRIM-19 to be primarily located in the cytoplasm in lung inflammation tissues, but located in the nucleus in lung cancer tissues. GRIM-19 expression occurs as an early phenomenon in the pathogenesis of lung cancer. Our study found that GRIM-19 expression in lung cancer is significantly lower compared to lung inflammation, exhibits a relationship with the histological type and clinical stage of lung cancer, and is a suitable target for the development of new lung cancer therapies.

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Abbreviations

GRIM-19:

Gene associated with retinoid-interferon-induced mortality-19

NSCLC:

Non-small cell lung cancer

SCLC:

Small cell lung cancer

CEA:

Carcinoembryonic antigen

NSE:

Neuron-specific enolase

CA19-9:

Carbohydrate antigen 19-9

CYFRA21-1:

Cytokeratin 19 fragment

FFPE:

Formalin-fixed and paraffin-embedded

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Acknowledgments

We thank Prof. Jiang-Ning Zhou, DhananjayaV Kalvakolanu and Wei-Hua Xiao for kind assistance. This work was supported by National Natural Science Foundation of China (81170030, 81100027) Annual Research Project of Anhui province (10021303028) and Province Department of Education natural science fund item in Anhui (KJ2011A176).

Conflict of interest

All the authors have no conflict of interest of this paper, and have not any financial and personal relationships with other people or organizations that could inappropriately influence their work.

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Authors and Affiliations

  1. Department of Geriatric Respiratory Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, People’s Republic of China

    Xiao-Yun Fan, Zi-Feng Jiang & Rong-Yu Liu

  2. The Institute of Respiratory Disease of Anhui Medical University, Hefei, 230022, Anhui, People’s Republic of China

    Xiao-Yun Fan, Zi-Feng Jiang & Rong-Yu Liu

  3. Department of Pathology, College of Basic Medicine of Anhui Medical University, Hefei, 230022, Anhui, People’s Republic of China

    Li Cai

  4. Life Science, University of Science and Technology of China, Hefei, 230027, Anhui, China

    Li Cai

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  1. Xiao-Yun Fan
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Correspondence to Rong-Yu Liu.

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Fan, XY., Jiang, ZF., Cai, L. et al. Expression and clinical significance of GRIM-19 in lung cancer. Med Oncol 29, 3183–3189 (2012). https://doi.org/10.1007/s12032-012-0249-1

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  • DOI: https://doi.org/10.1007/s12032-012-0249-1

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