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Jun activation domain-binding protein 1 expression in oral squamous cell carcinomas inversely correlates with the cell cycle inhibitor p27

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Abstract

The Jun activation domain-binding protein 1 (Jab1) may be involved in degradation of the cyclin-dependent kinase inhibitor p27, but it has not been clarified. In this study, we observed expression levels of Jab1 and p27 in oral squamous cell carcinoma (OSCC) and normal oral mucosa tissue and evaluated whether the Jab1 expression is correlated with p27 protein levels and how it is clinically relevant OSCC. The clinicopathological features and immunohistochemical expression levels of Jab1 and p27 proteins were immunohistochemically studied in 206 specimens from patients who underwent surgical resection for OSCC. Survival analyses were performed by using the Kaplan–Meier method. Jab1 overexpression was detected in 83% (171 of 206) of OSCCs and 19% (4 of 21) of normal oral mucosa. While p27 expression was 60% in OSCCs. We found an inverse correlation between Jab1 and p27 expression levels (P < 0.001). Kaplan–Meier survival analysis showed that Jab1 overexpression and p27 low expression were significantly associated with poor prognosis of patients. Our findings suggest that Jab1 expression is inversely correlated with p27 expression levels, suggesting that Jab1 overexpression contributes to pathogenesis of OSCC by degradating p27 expression. Furthermore, control of Jab1 could be a novel target of therapy in OSCCs.

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Acknowledgments

This study was supported by Science and Technology Program in Shaanxi Province of China (2009K17-3, 2010K14-3, 2011K13-3), the Fundamental Research Funds for the Central Universities (xjj20100216).

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Authors and Affiliations

  1. Department of Oral Maxillofacial Surgery, Stomatological Hospital, College of Medicine, Xi’an Jiaotong University, Xi’an, 710004, Shaanxi, People’s Republic of China

    Ling Gao, Shuo Huang, Wenhao Ren, Lu Zhao, Jingwei Li, Keqian Zhi & Yincheng Zhang

  2. Department of Oral Pathology, Stomatological Hospital, College of Medicine, Xi’an Jiaotong University, Xi’an, 710004, Shaanxi, People’s Republic of China

    Hong Qi

  3. Key Laboratory of Environment and Genes Related to Diseases, College of Medicine, Xi’an Jiaotong University, Xi’an, 710061, Shaanxi, People’s Republic of China

    Ling Gao & Chen Huang

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  1. Ling Gao
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  2. Shuo Huang
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  3. Wenhao Ren
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  4. Lu Zhao
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  5. Jingwei Li
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  6. Keqian Zhi
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  7. Yincheng Zhang
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  8. Hong Qi
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  9. Chen Huang
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Correspondence to Keqian Zhi.

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Gao, L., Huang, S., Ren, W. et al. Jun activation domain-binding protein 1 expression in oral squamous cell carcinomas inversely correlates with the cell cycle inhibitor p27. Med Oncol 29, 2499–2504 (2012). https://doi.org/10.1007/s12032-012-0177-0

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  • DOI: https://doi.org/10.1007/s12032-012-0177-0

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