Skip to main content

Advertisement

SpringerLink
Log in

Role of the recently identified dysadherin in E-cadherin adhesion molecule downregulation in head and neck cancer

  • Review Article
  • Published:
Medical Oncology Aims and scope Submit manuscript

Abstract

Dysadherin is a cancer-related cell membrane glycoprotein, recently identified, playing an important role in tumor progression and metastasis. In the present minireview article, we are focusing on the role of dysadherin in E-cadherin downregulation, the various expression patterns of the molecule in head and neck cancer as well as its potential role as a molecular target for future applications in diagnosis, clinical routine and prognosis of the disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Aoki S, Nakanishi Y, Akimoto S, et al. Prognostic significance of laminin-5 gamma2 chain expression in colorectal carcinoma: immunohistochemical analysis of 103 cases. Dis Colon Rectum. 2002;45(11):1520–7.

    Article  PubMed  Google Scholar 

  2. Batistatou A, Charalabopoulos K, Nakanishi Y, Vagianos C, Hirohashi S, Agnantis N, Scopa C. Differential expression of dysadherin in papillary thyroid carcinoma and microcarcinoma: correlation with E-cadherin. Endocr Pathol. 2008;19:197–202.

    Article  PubMed  Google Scholar 

  3. Batistatou A, Scopa C, Ravazoula P, et al. Involvement of dysadherin and E-cadherin in the development of testicular tumors. Br J Cancer. 2005;93(12):1382–7.

    Article  PubMed  CAS  Google Scholar 

  4. Batistatou A, Peschos D, Tsanou H. In breast carcinoma dysadherin expression is correlated with invasiveness but not with E-cadherin. Br J Cancer. 2007;96(9):1404–8.

    PubMed  CAS  Google Scholar 

  5. Batistatou A, Makrydimas G, Zagorianakou N, et al. Expression of dysadherin and E-cadherin in trophoblastic tissue in normal and abnormal pregnancies. Placenta. 2007;28(5–6):590–2.

    Article  PubMed  CAS  Google Scholar 

  6. Batistatou A, Charalabopoulos A, Scopa C, et al. Expression patterns of dysadherin and E-cadherin in lymph node metastases of colorectal carcinoma. Virchows Arch. 2006;448(6):763–7.

    Article  PubMed  CAS  Google Scholar 

  7. Bonitsis N, Batistatou A, Karantima S, et al. The role of E-cadherin/catenin complex in malignant melanoma. Exp Oncol. 2006;28(3):187–93.

    PubMed  CAS  Google Scholar 

  8. Bosch FX, Andl C, Abel U, et al. E-cadherin is a selective and strongly dominant prognostic factor in squamous cell carcinoma: a comparison of E-cadherin with desmosomal components. Int J Cancer. 2005;114(5):779–90.

    Article  PubMed  CAS  Google Scholar 

  9. Charalabopoulos K, Binolis J, Karkabounas S. Adhesion molecules in carcinogenesis. Exp Oncol. 2002;24(4):249–57.

    CAS  Google Scholar 

  10. Charalabopoulos K, Mittari E, Karakosta A, et al. Integrins adhesion molecules and some of their ligands in laryngeal cancer. Exp Oncol. 2005;27(2):86–90.

    PubMed  CAS  Google Scholar 

  11. Charalabopoulos K, Tsambalas S, Syrigos K, et al. Correlation of E-cadherin expression with clinicopathological data in patients suffering from transitional cell carcinoma of the bladder. Exp Oncol. 2003;25(3):180–5.

    CAS  Google Scholar 

  12. El-Hariry I, Pignatelli M. Adhesion molecules: opportunities for modulation and a paradigm for novel therapeutic approaches in cancer. Expert Opin Investig Drugs. 1997;6(10):1465–78.

    Article  PubMed  CAS  Google Scholar 

  13. Felding-Habermann B. Integrin adhesion receptors in tumor metastasis. Clin Exp Metastasis. 2003;20(3):203–13.

    Article  PubMed  CAS  Google Scholar 

  14. Georgolios A, Batistatou A, Manolopoulos L, et al. Role and expression patterns of E-cadherin in head and neck squamous cell carcinoma. J Exp Clin Cancer Res. 2006;25(1):5–14.

    PubMed  CAS  Google Scholar 

  15. Grandis JR, Tweardy DJ. Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer. Cancer Res. 1993;53(15):3579–84.

    PubMed  CAS  Google Scholar 

  16. Gupta A, Deshpande CG, Badve S. Role of E-cadherins in development of lymphatic tumor emboli. Cancer. 2003;97(9):2341–7.

    Article  PubMed  Google Scholar 

  17. Hirohashi S. Inactivation of the E-cadherin-mediated cell adhesion system in human cancers. Am J Pathol. 1998;153(2):333–9.

    Article  PubMed  CAS  Google Scholar 

  18. Ino Y, Gotoh M, Sakamoto M, et al. Dysadherin, a cancer-associated cell membrane glycoprotein, downregulates E-cadherin and promotes metastasis. Proc Natl Acad Sci USA. 2002;99(1):365–70.

    Article  PubMed  CAS  Google Scholar 

  19. Ioachim E, Peschos D, Goussia A, et al. Expression patterns of cyclins D1, E in laryngeal epithelial lesions correlation with other cell cycle regulators (p53, pRb, Ki-67, PCNA) and clinicopathological features. J Exp Clin Cancer Res. 2004;23(2):277–83.

    PubMed  CAS  Google Scholar 

  20. Kawano T, Nakamura Y, Yanoma S, et al. Expression of E-cadherin, and CD44s and CD44v6 and its association with prognosis in head and neck cancer. Auris Nasus Larynx. 2004;31(1):35–41.

    Article  PubMed  Google Scholar 

  21. Kyzas PA, Stefanou D, Batistatou A, et al. Dysadherin expression in head and neck squamous cell carcinoma: association with lymphangiogenesis and prognostic significance. Am J Surg Pathol. 2006;30(2):185–93.

    Article  PubMed  Google Scholar 

  22. Lewis JE, Jensen PJ, Johnson KR, et al. E-cadherin mediates adherens junction organization through protein kinase C. J Cell Sci. 1994;107(Pt 12):3615–21.

    PubMed  CAS  Google Scholar 

  23. Liang J, Zheng H, Xiao H, et al. Dysadherin expression in gastrointestinal stromal tumors. Pathol Res Prac. 2009;205:445–50.

    Article  CAS  Google Scholar 

  24. Lubarski I, Pihakaski-Maunsbach K, Karlish SJ, et al. Interaction with the Na, K-ATPase and tissue distribution of FXYD5 (related to ion channel). J Biol Chem. 2005;280(45):37717–24.

    Article  PubMed  CAS  Google Scholar 

  25. Maehata Y, Hirahasi M, Aishima S, et al. Significance of dysadherin end E-cadherin expression in differentiated-type gastric carcinoma with submucosal invasion. Hum Pathol. 2011;42:558–67.

    Article  PubMed  CAS  Google Scholar 

  26. Maurizi M, Scambia G, Benedetti, Panici P, et al. EGF receptor expression in primary laryngeal cancer: correlation with clinico-pathological features and prognostic significance. Int J Cancer. 1992;52(6):862–6.

    Article  PubMed  CAS  Google Scholar 

  27. Mitselou A, Ioachim E, Peschos D, et al. E-cadherin adhesion molecule and syndecan-1 expression in various thyroid pathologies. Exp Oncol. 2007;29(1):54–60.

    PubMed  CAS  Google Scholar 

  28. Mitselou A, Batistatou A, Nakanishi Y, Hirohashi S, Vougiouklakis T, Charalabopoulos K. Comparison of the dysadherin and E-cadherin expression in primary lung cancer and metastatic sites. Hist Histopathol. 2010;25:1257–67.

    Google Scholar 

  29. Mittari E, Charalabopoulos A, Batistatou A, et al. The role E-cadherin/catenin complex in laryngeal cancer. Exp Oncol. 2005;27(4):257–61.

    PubMed  CAS  Google Scholar 

  30. Moon C, Oh Y, Roth JA. Current status of gene therapy for lung cancer and head and neck cancer. Clin Cancer Res. 2003;9(14):5055–67.

    PubMed  CAS  Google Scholar 

  31. Muramatsou H, Akimoto T, Maebayashi K, Kita D, Mitsuhashi N. Prognostic significance of dysadherin and E-cadherin expression in patients with head and neck cancer treated by radiation therapy. Anticancer Res. 2008;28:3859–64.

    Google Scholar 

  32. Nakamura E, Sugihara H, Bamba M, et al. Dynamic alteration of the E-cadherin/catenin complex during cell differentiation and invasion of undifferentiated-type gastric carcinomas. J Pathol. 2005;205(3):349–58.

    Article  PubMed  CAS  Google Scholar 

  33. Nakanishi Y, Akimoto S, Sato Y, et al. Prognostic significance of dysadherin expression in tongue cancer: immunohistochemical analysis of 91 cases. Appl Immunohistochem Mol Morphol. 2004;12(4):323–8.

    Article  PubMed  CAS  Google Scholar 

  34. Nam J, Hirohasi S, Wakefield L. Dysadherin: a new player in cancer progression. Cancer Lett. 2007;255:161–9.

    Article  PubMed  CAS  Google Scholar 

  35. Nishizawa A, Nakanishi Y, Yoshimura K, et al. Clinicopathologic significance of dysadherin expression in cutaneous malignant melanoma: immunohistochemical analysis of 115 patients. Cancer. 2005;103(8):1693–700.

    Article  PubMed  CAS  Google Scholar 

  36. Ohene-Abuakwa Y, Pignatelli M. Adhesion molecules as diagnostic tools in tumor pathology. Int J Surg Pathol. 2000;8(3):191–200.

    Article  PubMed  CAS  Google Scholar 

  37. Ohene-Abuakwa Y, Pignatelli M. Adhesion molecules in cancer biology. Adv Exp Med Biol. 2000;465:115–26.

    Article  PubMed  CAS  Google Scholar 

  38. Park J, Kim R, Lee Y, Kim S, et al. Dysadherin can enhance tumorigenesis by conferring properties of stem-like cells to hepatocellular carcinoma cells. J Hepatol. 2011;54:122–31.

    Article  PubMed  CAS  Google Scholar 

  39. Rhee D, Wenig BM, Smith RV. The significance of immunohistochemically demonstrated nodal micrometastases in patients with squamous cell carcinoma of the head and neck. Laryngoscope. 2002;112(11):1970–4.

    Article  PubMed  Google Scholar 

  40. Richards FM, McKee SA, Rajpar MH, et al. Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer. Hum Mol Genet. 1999;8(4):607–10.

    Article  PubMed  CAS  Google Scholar 

  41. Sanderson RJ, Montague ML. Surgical management of head and neck malignancy. Surgeon. 2004;2(1):7–14.

    Article  PubMed  CAS  Google Scholar 

  42. Sato H, Ino Y, Miura A, et al. Dysadherin: expression and clinical significance in thyroid carcinoma. J Clin Endocrinol Metab. 2003;88(9):4407–12.

    Article  PubMed  CAS  Google Scholar 

  43. Schuler Y, Lee-Thedieck C, Geiger K, et al. Osteoblast-secreted factors enhance the expression of dysadherin and CCL2-dependent migration of renal carcinoma cells. Int J Cancer. (2011). (Ep. in print).

  44. Shimada Y, Hashimoto Y, Kan T, Kawamura, et al. Prognostic significance of dysadherin expression in esophageal squamous cell carcinoma. Oncology. 2004;67:73–80.

    Article  PubMed  CAS  Google Scholar 

  45. Shimamura T, Sakamoto M, Ino Y, et al. Dysadherin overexpression in pancreatic ductal adenocarcinoma reflects tumor aggressiveness: relationship to E-cadherin expression. J Clin Oncol. 2003;21(4):659–67.

    Article  PubMed  CAS  Google Scholar 

  46. Sturgis EM, Wei Q, Spitz MR. Descriptive epidemiology and risk factors for head and neck cancer. Semin Oncol. 2004;31(6):726–33.

    Article  PubMed  Google Scholar 

  47. Tamura M, Ohta Y, Tsunezuka Y, et al. Significance of dysadherin expression in patients with non-small cell lung cancer. J Thorac Cardiovasc Surg. 2005;130(3):740–5.

    Article  PubMed  CAS  Google Scholar 

  48. Tsuiji H, Takasaki S, Sakamoto M, et al. Aberrant O-glycosylation inhibits stable expression of dysadherin, a carcinoma-associated antigen, and facilitates cell–cell adhesion. Glycobiology. 2003;13(7):521–7.

    Article  PubMed  CAS  Google Scholar 

Download references

Conflicts of interest

None.

Author information

Authors and Affiliations

  1. Department of Otorhinolaryngology, Virginia Commonwealth University, Richmond, VA, USA

    Alexandros Georgolios

  2. Department of Otorhinolaryngology, General Hospital of Rethymnon, P.O. Box 269, 74100, Rethymnon, Crete, Greece

    Anna Eleftheriadou

  3. Department of Pathology, Medical School, University of Ioannina, Ioannina, Greece

    Anna Batistatou

  4. Department of Physiology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece

    Kostandinos Charalabopoulos

Authors
  1. Alexandros Georgolios
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Anna Eleftheriadou
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Anna Batistatou
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kostandinos Charalabopoulos
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Anna Eleftheriadou.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Georgolios, A., Eleftheriadou, A., Batistatou, A. et al. Role of the recently identified dysadherin in E-cadherin adhesion molecule downregulation in head and neck cancer. Med Oncol 29, 1463–1467 (2012). https://doi.org/10.1007/s12032-011-0118-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12032-011-0118-3

Keywords

Search

Navigation