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Upregulated INHBA expression is associated with poor survival in gastric cancer

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Abstract

Expression microarrays are widely used for investigating the candidate molecular targets in human cancer. While genome-wide expression signatures screened by gene set enrichment analysis (GSEA) were not performed in Chinese gastric cancer (GC). To gain new molecular targets for GC, GSEA analysis was performed. In the present study, GSEA were used to pick out differentially expressed gene sets of our database. Total RNA of paired tissue samples (n = 48) and a tissue microarray containing 132 paired tissues were used to further validate expression levels of INHBA and its correction with clinicopathological factors. Upregulated INHBA expression in gastric cancer was screened and further confirmed by qPCR and immunostaining analysis. Increased INHBA expression was significantly correlated with the diameter of cancer and depth of tumor invasion. Patients with higher expression levels of INHBA had a shorter disease-free survival rate. It was effective to gain new molecular targets for GC by GSEA analysis. INHBA may be a poor survival indicator of GC.

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Acknowledgments

This study was supported by grants from the Fundamental Key Science Foundation of Science and Technology Commission of Shanghai Municipality (No. 09JC1412400, 10411967300), Public Scientific Research Platform of Hospital of Grade A at the Tertiary Level of Shanghai (No. SHDC12007704).

Conflict of interests

The authors declare that they have no conflict of interests.

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Authors and Affiliations

  1. Department of General Surgery, Shanghai First People’s Hospital, College of Medicine, Shanghai Jiao Tong University, 85 Wujin Road, 200080, Shanghai, China

    Quan Wang, Yu-Gang Wen, Da-Peng Li, Jun Xia, Chong-Zhi Zhou, Dong-Wang Yan & Zhi-Hai Peng

  2. Department of Pathology, Shanghai First People’s Hospital, College of Medicine, Shanghai Jiao Tong University, 85 Wujin Road, 200080, Shanghai, China

    Hua-Mei Tang

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  1. Quan Wang
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  2. Yu-Gang Wen
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  4. Jun Xia
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  7. Hua-Mei Tang
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Correspondence to Zhi-Hai Peng.

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Quan Wang and Yu-Gang Wen contribute equally to this work.

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Wang, Q., Wen, YG., Li, DP. et al. Upregulated INHBA expression is associated with poor survival in gastric cancer. Med Oncol 29, 77–83 (2012). https://doi.org/10.1007/s12032-010-9766-y

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  • DOI: https://doi.org/10.1007/s12032-010-9766-y

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