Skip to main content

Advertisement

SpringerLink
Log in

Lingual metastasis as an initial presentation of renal cell carcinoma

  • Original Paper
  • Published:
Medical Oncology Aims and scope Submit manuscript

Abstract

Distant metastasis of malignant neoplasm to the oral soft tissue is extremely rare. We report a case of renal cell carcinoma (RCC) metastasizing to the tongue. A 47-year-old man visited our hospital with chief complaint of a lump on the middle third of the dorsum of his tongue and the lesion fell off from the tongue. Although histopathological diagnosis of the mass was granuloma teleangiectaticum, similar nodule reappeared in the same area 2 weeks later. The second lesion was composed of granuloma teleangiectaticum and aggregation of neoplastic clear cells in ductal arrangement. The clear cells were immunohistochemically positive for EMA and CD10. The abdominal CT scan revealed a 5.5 cm mass in the left kidney, suggesting RCC. Thus, the lingual lesion was consistent with metastatic RCC. There has been no recurrence for 2 years after the radical nephrectomy and local excision of the tongue.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

References

  1. Pritchyk KM, et al. Metastatic renal cell carcinoma to the head and neck. Laryngoscope. 2002;112(9):1598–602.

    Article  PubMed  Google Scholar 

  2. Zegarelli DJ, et al. Metastatic tumor to the tongue. Report of twelve cases. Oral Surg Oral Med Oral Pathol. 1973;35(2):202–11.

    Article  PubMed  CAS  Google Scholar 

  3. Pires FR, et al. Metastatic renal cell carcinoma to the oral cavity and clear cell mucoepidermoid carcinoma: comparative clinicopathologic and immunohistochemical study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109(4):e22–7.

    Article  PubMed  Google Scholar 

  4. Yamamoto D, et al. Metastatic gastric tumor from renal cell carcinoma. Gastric Cancer. 2009;12(3):170–3.

    Article  PubMed  CAS  Google Scholar 

  5. Rivera AL, et al. Useful immunohistochemical markers in differentiating hemangioblastoma versus metastatic renal cell carcinoma. Neuropathology. 30 March 2010 [Epub ahead of print]

  6. Friedlander AH, Singer R. Renal adenocarcinoma of the kidney with metastasis to the tongue. J Am Dent Assoc. 1978;97(6):989–91.

    PubMed  CAS  Google Scholar 

  7. Sgouras ND, et al. An unusual presentation of a metastatic hypernephroma to the frontonasal region. Ann Plast Surg. 1995;34(6):653–6.

    Article  PubMed  CAS  Google Scholar 

  8. Gottlieb MD, Roland JT Jr. Paradoxical spread of renal cell carcinoma to the head and neck. Laryngoscope. 1998;108(9):1301–5.

    Article  PubMed  CAS  Google Scholar 

  9. Boles R, Cerny J. Head and neck metastases from renal carcinomas. Mich Med. 1971;70(16):616–8.

    PubMed  CAS  Google Scholar 

  10. Ol’shevskii VA, Fofanov VV, Arifmetikova TN. Metastasis of clear-cell cancer of the kidney to the tongue. Arkh Patol. 1984;46(10):85–6.

    PubMed  Google Scholar 

  11. Azam F, Abubakerr M, Gollins S. Tongue metastasis as an initial presentation of renal cell carcinoma: a case report and literature review. J Med Case Reports. 2008;2:249.

    Article  PubMed  Google Scholar 

  12. Cheng ET, Greene D, Koch RJ. Metastatic renal cell carcinoma to the nose. Otolaryngol Head Neck Surg. 2000;122(3):464.

    Article  PubMed  CAS  Google Scholar 

  13. Fukuda M, et al. A case series of 9 tumors metastatic to the oral and maxillofacial region. J Oral Maxillofac Surg. 2002;60(8):942–4.

    Article  PubMed  Google Scholar 

  14. Marioni G, et al. Uncommon metastatic site of renal adenocarcinoma: the oral tongue. Acta Otolaryngol. 2004;124(2):197–201.

    Article  PubMed  Google Scholar 

  15. Simo R, et al. Metastatic renal cell carcinoma to the nose and paranasal sinuses. Head Neck. 2000;22(7):722–7.

    Article  PubMed  CAS  Google Scholar 

  16. Shibayama T, et al. Disappearance of metastatic renal cell carcinoma to the base of the tongue after systemic administration of interferon-alpha. Eur Urol. 1993;24(2):297–9.

    PubMed  CAS  Google Scholar 

  17. Basso M, Cassano A, Barone C. A survey of therapy for advanced renal cell carcinoma. Urol Oncol. 2009;28(2):121–33.

    Article  PubMed  Google Scholar 

  18. Will TA, Agarwal N, Petruzzelli GJ. Oral cavity metastasis of renal cell carcinoma: a case report. J Med Case Reports. 2008;2:313.

    Article  PubMed  Google Scholar 

  19. Campbell SC, Novick AC, Bukowski RM. Renal tumors. In: Wein AJ, editor. Campbell-Walsh urology, vol. 2. 9th ed. Philadelphia: Saunders Elsevier; 2007. p. 1582–632.

    Google Scholar 

  20. Satomi Y, et al. Three cases of hypernephroma metastasis in the otorhinopharyngolaryngeal region (parotid gland, nasal cavity, tongue and gingiva). Jpn J Clin Urol. 1974;28(8):611–6.

    Google Scholar 

  21. Fitzgerald RH, et al. Renal cell carcinoma involving oral soft tissues. J Oral Maxillofac Surg. 1982;40(9):604–6.

    Article  PubMed  Google Scholar 

  22. Kitao K, et al. Metastatic Gravitz tumor of the base of tongue. A case report. Jibi Inkoka. 1986;58(1):67–70.

    Google Scholar 

  23. Inai T, et al. A renal cell carcinoma with metastatis to the tongue. Acta Urol Jpn. 1987;33(8):1240–3.

    CAS  Google Scholar 

  24. Matsumoto A, Iio S. Metastasis of renal cell carcinoma to the tongue: a case report. Nishinihon J Urol. 1987;49:1147–9.

    Google Scholar 

  25. Kapoor VK, et al. Renal cell carcinoma metastatic to the tongue. J Indian Med Assoc. 1987;85(4):119–20.

    PubMed  CAS  Google Scholar 

  26. Madison JF, et al. Pathologic quiz case 2. Arch Otolaryngol Head Neck Surg. 1988;114(5):570–3.

    PubMed  CAS  Google Scholar 

  27. Ishikawa J, et al. Renal cell carcinoma metastatic to the tongue: a case report. Acta Urol Jpn. 1991;37(3):263–5.

    CAS  Google Scholar 

  28. Okabe Y, et al. View from beneath: pathology in focus. Renal cell carcinoma metastasis to the tongue. J Laryngol Otol. 1992;106(3);282–4.

    Article  PubMed  CAS  Google Scholar 

  29. Ziyada WF, et al. Expectorated tissue leading to diagnosis of renal adenocarcinoma. J Laryngol Otol. 1994;108(12):1108–10.

    Article  PubMed  CAS  Google Scholar 

  30. Airoldi M, et al. Head and neck metastases of renal cancer after nephrectomy: a report of 2 cases. Tumori. 1996;81(3):213–4.

    Google Scholar 

  31. Aguirre A, Rinaggio J. Lingual metastasis of renal cell carcinoma. J Oral Maxillofac Surg. 1996;54(3):344–6.

    Article  PubMed  CAS  Google Scholar 

  32. Konya E, et al. Two cases of renal cell carcinoma detected by metastasis to another organ. Hinyokika Kiyo. 1997;43(9):647–50.

    PubMed  CAS  Google Scholar 

  33. Tomita T, et al. Palliative radiotherapy for lingual metastasis of renal cell carcinoma. Auris Nasus Larynx. 1998;25(2):209–14.

    Article  PubMed  CAS  Google Scholar 

  34. Navarro F, et al. Metastatic renal cell carcinoma to the head and neck area. Tumori. 2000;86(1):88–90.

    PubMed  CAS  Google Scholar 

  35. Goel MC, et al. Lingual metastasis from renal cell carcinoma management and review of the literature. Urol Int. 2003;71(4):418–21.

    Article  PubMed  Google Scholar 

  36. Lang EE. A case of renal cell carcinoma metastatic to the nose and tongue. Ear Nose Throat J. 2003;82(5):382–3.

    PubMed  Google Scholar 

  37. Kyan A, et al. Renal cell carcinoma to the base of tongue: a case report. Hinyokika Kiyo. 2004;50(11):791–3.

    PubMed  Google Scholar 

  38. Tachi T, et al. Renal cell carcinoma with metastasis to the tongue. Pract otol (Kyoto). 2005;98(7):543–6.

    Google Scholar 

  39. Torres-Carranza E, et al. Airway obstruction due to metastatic renal cell carcinoma to the tongue. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3):E76–78.

    Article  PubMed  Google Scholar 

  40. Cochrane TJ. Renal cell carcinoma: a rare metastasis to the tongue—a case report. Dent Update. 2006;33(3):186–7.

    Google Scholar 

  41. Tanaka Y, et al. A case of renal carcinoma metastatic to the tongue. Pract otol (Kyoto). 2007;100(5):375–8.

    Google Scholar 

  42. Basely M, et al. A rare presentation of metastatic renal clear cell carcinoma to the tongue seen on FDG PET. Clin Nucl Med. 2009;34(9):566–9.

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

We thank the staff of the Department of Radiology and Cancer Biology, Nagasaki University Graduate School of Biomedical Sciences.

Author information

Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, Unit of Translational Medicine, Sciences, Course of Medical and Dental Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

    Izumi Yoshitomi, Goro Kawasaki & Akio Mizuno

  2. Department of Nephro-Urology, Unit of Translational Medicine, Sciences, Course of Medical and Dental Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

    Masaharu Nishikido

  3. Department of Pathology, Nagasaki University Hospital, Nagasaki, Japan

    Tomayoshi Hayashi

  4. Department of Oral Pathology and Bone Metabolism, Unit of Basic Medical Sciences, Course of Medical and Dental Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

    Shuichi Fujita & Tohru Ikeda

Authors
  1. Izumi Yoshitomi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Goro Kawasaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Akio Mizuno
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Masaharu Nishikido
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Tomayoshi Hayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Shuichi Fujita
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Tohru Ikeda
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Izumi Yoshitomi.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yoshitomi, I., Kawasaki, G., Mizuno, A. et al. Lingual metastasis as an initial presentation of renal cell carcinoma. Med Oncol 28, 1389–1394 (2011). https://doi.org/10.1007/s12032-010-9596-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12032-010-9596-y

Keywords

Search

Navigation