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Preoperative serum carbohydrate antigen 125 level is an independent negative prognostic marker for overall survival in colorectal cancer

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Abstract

To evaluate the prognostic value of preoperative serum carbohydrate antigen19-9 (CA19-9), carcinoembryonic antigen (CEA), and carbohydrate antigen 125 (CA125) for overall survival (OS) in patients with colorectal cancer (CRC). Preoperative serum CA19-9, CEA, and CA125 levels were detected by C12 protein chip diagnostic system in 80 patients with CRC, and the association of their preoperative status with the patients’ OS was analyzed. Patients with positive preoperative serum CA19-9, CA125, and CEA had a worse survival comparing with those negative patients, the difference in CA19-9 and CA125 reached statistical significance (Log rank test, P < 0.05), but the difference of CEA did not achieve statistical significance (Log rank test, P > 0.05). The OS of patients with CRC with three positive tumor markers (TMs) <1 or 2 positive TMs < negative TM, simultaneously positive serum CA19-9, CEA, and CA125 was the most dismal predicting factor for OS. Spearman correlations revealed that the preoperative serum status of CA19-9 (P = 0.000), CEA (P = 0.000), and CA125 (P = 0.000) had correlations with stage; the preoperative serum CA125 status (r = −0.385, P = 0.000) and stage (r = −0.457, P = 0.000) and location (r = 0.223, P = 0.047) had correlations with OS. Multivariate analysis with Cox regression model showed that only stage (P = 0.000) and the preoperative serum CA125 status (P = 0.016) were independent prognostic factors for OS of patients with CRC. The preoperative status of serum CA19-9, CEA, and CA125 had correlations with CRC stage. The simultaneously positive serum CA19-9, CEA, and CA125 was the most dismal predicting factor for OS of patients with CRC. Preoperative serum CA125 status and stage were independent prognostic factors for OS of CRC.

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Abbreviations

CRC:

Colorectal cancer

CA19-9:

Carbohydrate antigen 19-9

CEA:

Carcinoembryonic antigen

CA125:

Carbohydrate antigen 125

TM:

Tumor marker

OS:

Overall survival

TNM:

Tumor-node-metastasis

C12:

12 Tumor-marker protein chip system

UICC:

International Union against Cancer

PPV:

Positive predicitive value

NPV:

Nagative predicitive value

CI:

Confidence interval

RR:

Relative risk

HIPEC:

Hyperthermic intraperitoneal chemotherapy

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Acknowledgments

Supported by Foundation for the Author of National Excellent Doctoral Dissertation of PR China (no. FANEDD-200464), the Science Fund for Creative Research Groups of the National Natural Science Foundation of China (no. 20621502 and 20921062).

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Authors and Affiliations

  1. Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Cancer Clinical Study Center & Hubei Key Laboratory on Tumor Biological Behaviors, No 169 Donghu Road, 430071, Wuhan, China

    Xue-Qin Yang, Yan Li, Chuang Chen, Chun-Wei Peng, Shao-ping Liu & Yang Liu

  2. Medical School of Jingchu University of Technology, 448000, Jingmen, China

    Xue-Qin Yang

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  1. Xue-Qin Yang
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  2. Yan Li
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  3. Chuang Chen
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Correspondence to Yan Li.

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Yang, XQ., Li, Y., Chen, C. et al. Preoperative serum carbohydrate antigen 125 level is an independent negative prognostic marker for overall survival in colorectal cancer. Med Oncol 28, 789–795 (2011). https://doi.org/10.1007/s12032-010-9518-z

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  • DOI: https://doi.org/10.1007/s12032-010-9518-z

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