Skip to main content
SpringerLink
Log in

Concomitant chemoradiotherapy with cisplatin and docetaxel followed by surgery and consolidation chemotherapy in patients with unresectable locally advanced non-small cell lung cancer

  • Original Paper
  • Published:
Medical Oncology Aims and scope Submit manuscript

Abstract

Aims To evaluate preoperative concomitant chemoradiation using cisplatin plus docetaxel followed by consolidation chemotherapy in patients with unresectable locally advanced non-small cell lung cancer (NSCLC). Patients and methods Medical records of patients with locally advanced unresectable NSCLC (stage IIIA and IIIB) treated with concomitant chemoradiotherapy using cisplatin + docetaxel combination followed by consolidation chemotherapy were retrospectively evaluated. All the patients were consecutively treated. Chemotherapy consisted of weekly cisplatin 20 mg/m2 and docetaxel 20 mg/m2 during radiotherapy. Radiotherapy dose was 58–66 Gy given in 2 Gy fractions, 5 days per week. The patients were subsequently referred to surgery if adequately downstaged. Consolidation chemotherapy using cisplatin and docetaxel both at doses 75 mg/m2 every 3 weeks followed local therapy in all patients. Results A total of 54 patients were evaluated (49 males, 5 females with a median age of 58 years; 41 [75.9%] stage IIIB and 13 [24.1%] IIIA). Twelve patients (22.2%) achieved pathologic complete response and 20 (37%) partial response. Downstaging was possible in 32 patients (59.3%). Twenty-six patients (48.1%) were operated after concomitant chemoradiotherapy (pneumonectomy [n = 2], lobectomy [n = 12], and wedge resection [n = 12]). Toxicity was tolerable. Median progression-free survival and overall survival (OS) for the entire cohort were 14 and 22 months, respectively. In resected patients (n = 26), median PFS and OS have not been reached with a median follow-up duration of 24 months. Conclusion Preoperative concomitant chemoradiation using weekly cisplatin and docetaxel followed by surgery and consolidation chemotherapy is effective and well tolerated in patients with unresectable locally advanced NSCLC.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Non-Small Cell Lung Cancer Collaborative Group. Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials. BMJ. 1995;311:899–909.

    Google Scholar 

  2. Furuse K, et al. Phase III study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vindesine and cisplatin in unresectable stage III non-small cell lung cancer. J Clin Oncol. 1999;17:2692–9.

    CAS  PubMed  Google Scholar 

  3. Curran WJ, et al. Long-term benefit is observed in a phase III comparison of sequential vs concurrent chemoradiation for patients with unresected stage III NSCLC: RTOG 9410. Proc Am Soc Clin Oncol. 2003;22:121. (Abstract 2499).

    Google Scholar 

  4. Kiura K, et al. Phase I/II study docetaxel and cisplatin with concurrent thoracic radiation therapy for locally advanced non-small cell lung cancer. Br J Cancer. 2003;89:795–802.

    Article  CAS  PubMed  Google Scholar 

  5. Albain KS, et al. Phase III study of concurrent chemotherapy, radiotherapy (CT/RT) versus CT/RT followed by surgical resection for stage IIIA (pN2) non-small-cell lung cancer: outcomes update of North Amrica Interfgroup 0139 (RTOG 9309). J Clin Oncol. 2005;23:7014.

    Google Scholar 

  6. Ahn YC, et al. Preoperative concurrent chemoradiotherapy for stage IIIA non-small cell lung cancer. Acta Oncol. 2001;40:588–92.

    Article  CAS  PubMed  Google Scholar 

  7. Stamatis G, et al. Preoperative chemoradiotherapy and surgery for selected non-small cell lung cancer IIIB subgroups: long-term results. Ann Thorac Surg. 1999;68:1144–9.

    Article  CAS  PubMed  Google Scholar 

  8. Katayama H, et al. Preoperative concurrent chemoradiotherapy with cisplatin and docetaxel in patients with locally advanced non-small cell lung cancer. Br J Cancer. 2004;90:979–84.

    Article  CAS  PubMed  Google Scholar 

  9. Edelman MJ, et al. Phase I/II trial of hyperfractionated radiation and chemotherapy followed by surgery in stage III lung cancer. Ann Thorac Surg. 2008;86:903–11.

    Article  PubMed  Google Scholar 

  10. Yap S-P, et al. Induction concurrent chemoradiotherapy using paclitaxel and carboplatin combination followed by surgery in locoregionally advanced non-small cell lung cancer—Asian experience. Ann Acad Med Singapore. 2008;37:377–82.

    PubMed  Google Scholar 

  11. Thomas M, et al. Effect of preoperative chemoradiation in addition to preoperative chemotherapy: a randomised trial in stage III non-small-cell lung cancer. Lancet Oncol. 2008;9:636–48.

    Article  PubMed  Google Scholar 

  12. Kaplan B, et al. Preliminary results of a phase II study of weekly paclitaxel (PTX) and carboplatin (CBDCA) administered concurrently with thoracic radiation therapy (TRT) followed by consolidation chemotherapy with PTX/CBDCA for stage III unresectable non-small-cell lung cancer (NSCLC). Am J Clin Oncol. 2004;27:603–10.

    Article  CAS  PubMed  Google Scholar 

  13. Belani CP, et al. Combined chemoradiotherapy regimens of paclitaxel and carboplatin for locally advanced non-small cell lung cancer: a randomized phase II locally advanced multi-modality protocol. J Clin Oncol. 2005;23:5883–93.

    Article  CAS  PubMed  Google Scholar 

  14. Hurria A, Kris MG. Management of lung cancer in older adults. CA Cancer J Clin. 2005;53:325–41.

    Article  Google Scholar 

  15. National Cancer Instıtute-Common Toxicity Criteria (NCI-CTC). NCI-CTC version 2.0, January 30; 1998

  16. Therasse P, Eisenhauer EA, Verveij J. RECIST revisited: a review of validation studies on tumor assessment. Eur J Cancer. 2006;42:1031–9.

    Article  CAS  PubMed  Google Scholar 

  17. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457–81.

    Article  Google Scholar 

  18. Fournel P, et al. Randomized phase III trial of sequential chemoradiotherapy compared with concurrent chemoradiotherapy in locally advanced non-small lung cancer: Groupe Lyon-Saint-Etienne d’Oncologie Thoracique-Groupe Français de Pneumo-Cancerologie NPC95-01 Study. J Clin Oncol. 2005;23:5910–7.

    Article  CAS  PubMed  Google Scholar 

  19. Le Chevalier T, et al. Randomized study of vinorelbine and cisplatin versus vindesine and cisplatin versus vinorelbin alone in advanced non-small cell lung cancer: results of European multicenter trial including 612 patients. J Clin Oncol. 1994;12:360–7.

    CAS  PubMed  Google Scholar 

  20. Bonomi P, et al. Comparison of survival and wuality of life in advanced non-small-cell lung cancer patients treated with two dose levels of paclitaxel combined with cisplatin versus etoposide with cisplatin: results of an Eastern Cooperative Oncology Group Trial. J Clin Oncol. 2000;18:623–31.

    CAS  PubMed  Google Scholar 

  21. Mudad R, et al. Concomitant weekly docetaxel, cisplatin and radiation therapy in locally advanced non-small cell lung cancer: a dose finding study. Lung Cancer. 2003;39:173–7.

    Article  PubMed  Google Scholar 

  22. Wu H-G, et al. Phase I study of weekly docetaxel and cisplatin concurrent with thoracic radiotherapy in stage III non- small cell lung cancer. Int Radiat Oncol Biol Phys. 2002;52:75–80.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medical Oncology, Gazi University Faculty of Medicine, Besevler, Ankara, 06500, Turkey

    Ali Osman Kaya, Suleyman Buyukberber, Mustafa Benekli, Ugur Coskun, Ramazan Yildiz, Banu Ozturk, Emel Yaman, Deniz Yamac & Aytug Uner

  2. Department of Medical Oncology, Gaziantep University Faculty of Medicine, Gaziantep, Turkey

    Alper Sevinc & Mehmet Emin Kalender

  3. Department of Radiation Oncology, Gazi University Faculty of Medicine, Ankara, Turkey

    Muge Akmansu

  4. Department of Radiation Oncology, Erciyes University Faculty of Medicine, Kayseri, Turkey

    Okan Orhan

Authors
  1. Ali Osman Kaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Suleyman Buyukberber
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mustafa Benekli
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ugur Coskun
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Alper Sevinc
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Muge Akmansu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Ramazan Yildiz
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Banu Ozturk
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Emel Yaman
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Mehmet Emin Kalender
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Okan Orhan
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Deniz Yamac
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Aytug Uner
    View author publications

    You can also search for this author in PubMed Google Scholar

Consortia

for Anatolian Society of Medical Oncology (ASMO)

Corresponding author

Correspondence to Suleyman Buyukberber.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kaya, A.O., Buyukberber, S., Benekli, M. et al. Concomitant chemoradiotherapy with cisplatin and docetaxel followed by surgery and consolidation chemotherapy in patients with unresectable locally advanced non-small cell lung cancer. Med Oncol 27, 152–157 (2010). https://doi.org/10.1007/s12032-009-9186-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12032-009-9186-z

Keywords

Search

Navigation