Skip to main content

Advertisement

SpringerLink
Log in

Tissue levels of adiponectin in breast cancer patients

  • Original Paper
  • Published:
Medical Oncology Aims and scope Submit manuscript

Abstract

Background

Adiponectin is a new adipocyte-secreted protein and associated with insulin-resistant status, such as type 2 diabetes mellitus and obesity. The inverse correlation between serum adiponectin levels and breast cancer risk was recently documented. On the other hand, the association of tissue adiponectin levels with breast cancer has not been previously reported. Thus, in the present study, the relationship between tissue adiponectin levels and breast cancer was evaluated.

Methods

We analyzed the correlation between tissue adiponectin levels and the occurrence of breast cancer in a case–control study comprising 27 women with diagnosed and histologically confirmed breast cancer and 33 women with fibroadenoma. In addition, the association of tissue adiponectin levels with the various classical risk factors, such as body mass index, menopausal status and, tumor size, stage, lymph node status, hormonal status were also studied.

Results

Tissue adiponectin levels in patients with breast cancer (0.75 ± 0.06) were significantly higher than those in controls (0.68 ± 0.1) (P = 0.02). The high tissue adiponectin levels were associated with significantly (P = 0.001) an increased risk for breast cancer compared with those in the low tissue adiponectin levels (OR, 1.34; 95% CI, 1.12–1.84) in breast cancer patients. In addition, postmenopausal women with the high tissue adiponectin levels showed a significantly (P = 0.003) an increased risk for breast cancer compared with women in low tissue adiponectin levels (OR, 1.63; 95% CI, 1.23–1.90). The correlation between BMI and breast cancer was not found (P > 0.05). Furthermore, the status of estrogen receptor, progesteron receptor, HER-2/neu receptor and lymph nodes involvement were established, no effect on the tissue adiponectin levels in patients with breast cancer and no correlations were detected among tumor stage, tumor size and the levels of tissue adiponectin (P > 0.05).

Conclusion

Our results suggest that the high tissue adiponectin levels significantly detected in breast cancer patients and associated with an increased risk for breast cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (adipose most abundant gene transcript 1). Biochem Biophys Res Commun 1996;221:286–9

    Article  PubMed  CAS  Google Scholar 

  2. Nakano Y, Tobe T, Choi-Miura NH, Mazda T, Tomita M. Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma. J Biochem 1996;120:803–12

    PubMed  CAS  Google Scholar 

  3. Hu E, Liang P, Spiegelman BM. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 1996;271:10697–703

    Article  PubMed  CAS  Google Scholar 

  4. Stefan N, Vazarova B, Funahashi T, Matsuzawa Y, Weyer C, Lindsay RS, Youngren JF, Havel PJ, Pratley RE, Bogardus C, Tataranni PA. Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans. Diabetes 2002;51:1884–8

    Article  PubMed  CAS  Google Scholar 

  5. Arita Y, Kihara S, Ouchi N, Maeda K, Kuriyama H, Okamoto Y, Kumada M, Hotta K, Nishida M, Takahashi M, Nakamura T, Shimomura I, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y. Adipocyte-derived plasma protein, adiponectin, acts as a platelets growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell. Circulation 2002;105:2893–8

    Article  PubMed  CAS  Google Scholar 

  6. Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF. A novel serum protein similar to Clq, produced exclusively in adipocytes. J Biol Chem 1995;270:26746–9

    Article  PubMed  CAS  Google Scholar 

  7. Brakenhielm E, Veitonmaki N, Cao R, Kihara S, Matsuzawa Y, Zhivotovsky B, Funahashi T, Cao Y. Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Proc Natl Acad Sci USA 2004;101:2476–81

    Article  PubMed  CAS  Google Scholar 

  8. Friedman JM. Obesity in the new millennium. Nature 2000;404:632–4

    PubMed  CAS  Google Scholar 

  9. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, Kuriyama H, Nishida M, Yamashita S, Okubo K, Matsubara K, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999;257:79–83

    Article  PubMed  CAS  Google Scholar 

  10. Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE, Tataranni PA. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 2001;86:1930–5

    Article  PubMed  CAS  Google Scholar 

  11. Calle EE, Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 2004;4:579–91

    Article  PubMed  CAS  Google Scholar 

  12. Ursin G, Longnecker MP, Haile RW, Greenland SA. Meta-analysis of body mass index and risk of premenopausal breast cancer. Epidemiology 1995;6:137–41

    Article  PubMed  CAS  Google Scholar 

  13. Van den Brandt PA, Spiegelman D, Yaun SS, Adami HO, Beeson L, Folsom AR, Fraser G, Goldbohm RA, Graham S, Kushi L, Marshall JR, Miller AB, Rohan T, Smith-Warner SA, Speizer FE, Willett WC, Wolk A, Hunter DJ. Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk. Am J Epidemiol 2000;152:514–27

    Article  PubMed  Google Scholar 

  14. Rose DP, Komninou D, Stephenson GD. Obesity, adipocytokines, and insulin resistance in breast cancer. Obes Rev 2004;5:153–65

    Article  PubMed  CAS  Google Scholar 

  15. Stephenson GD, Rose DP. Breast cancer and obesity: an update. Nutr Cancer 2003;45:1–16

    Article  PubMed  CAS  Google Scholar 

  16. Petridou E, Mantzoros C, Dessypris N, Koukoulomatis P, Addy C, Voulgaris Z, Chrousos G, Trichopoulos D. Plasma adiponectin concentrations in relation to endometrial cancer: a case–control study in Greece. J Clin Endocrinol Metab 2003;88:993–7

    Article  PubMed  CAS  Google Scholar 

  17. Miyoshi Y, Funahashi T, Kihara S, Taguchi T, Tamaki Y, Matsuzawa Y, Noguchi S. Association of serum adiponectin levels with breast cancer risk. Clin Can Res 2003;9:5699–704

    CAS  Google Scholar 

  18. Mantzoros C, Petridou E, Dessypris N, Charilaos C, Dalamaga M, Alexe DM, Papadimantis Y, Markopoulos C, Spanos E, Chrousos G, Trichopoulos D. Adiponectin and breast cancer risk. J Clin Endocrinol Metab 2004;89:1102–7

    Article  PubMed  CAS  Google Scholar 

  19. Chen DC, Chung YF, Yeh YT, Chaung HC, Kuo FC, Fu OY, Chen HY, Hou MF, Yuan SS. Serum adiponectin and leptin levels in Taiwanese breast cancer patients. Cancer Lett 2006;237:109–14

    Article  PubMed  CAS  Google Scholar 

  20. Woodward WA, Strom EA, Tucker SL, McNeese MD, Perkins GH, Schechter NR, Singletory SE, Theriault RL, Hortobagyi GN, Hunt KK, Buchholz TA. Changes in the 2003 American Joint Committee on Cancer staging for breast cancer dramatically affect stage-specific survival. J Clin Oncol 2002;21:4467–8

    Google Scholar 

  21. Hou MF, Lin SB, Yuan SS, Tsai SM, Wu SH, Ou-Yang F, Hesieh JS, Tsai KB, Huang TJ, Tsai LY. The clinical significance between activation of nuclear factor kappa B transcription factor and overexpression of HER-2/neu oncoprotein in Taiwanese patients with breast cancer. Clin Chim Acta 2003;334:137–44

    Article  PubMed  CAS  Google Scholar 

  22. Marshak DR. Strategies for protein purification and characterization: a laboratory course manual. Plainview, NY: Cold Spring Harbor Laboratory Press; 1996

  23. Stephard DA. The 1975 declaration of Helsinki and consent. Can Med Assoc J 1976;115:1191–2

    Google Scholar 

  24. Michels KB, Solomon CG, Hu FB, Rosner BA, Hankinson SE, Colditz GA, Manson JE. Type 2 diabetes and subsequent incidence of breast cancer in the Nurses’ Health Study. Diabetes Care 2003;26:1752–8

    Article  PubMed  Google Scholar 

  25. Stoll BA. Western nutrition and the insulin resistance syndrome: a link to breast cancer. Eur J Clin Nutr 1999;53:83–7

    Article  PubMed  CAS  Google Scholar 

  26. Yamamoto Y, Hirose H, Saito I, Tomita M, Taniyama M, Matsubara K, Okazaki Y, Ishii T, Nishikai K, Saruta T. Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein–cholesterol, independent of body mass index, in the Japanese population. Clin Sci (Lond) 2002;103:137–42

    Article  CAS  Google Scholar 

  27. Stefan N, Bunt JC, Salbe AD, Funahashi T, Matsuzawa Y, Tataranni PA. Plasma adiponectin concentrations in children: relationships with obesity and insulinemia. J Clin Endocrinol Metab 2002;87:4652–6

    Article  PubMed  CAS  Google Scholar 

  28. Bruning PF, Bonfrer JM, van Noord PA, Hart AA, de Jong-Bakker M, Nooijen WJ. Insulin resistance and breast-cancer risk. Int J Cancer 1992;52:511–6

    Article  PubMed  CAS  Google Scholar 

  29. Del Giudice ME, Fantus IG, Ezzat S, McKeown-Eyssen G, Page D, Goodwin PJ. Insulin and related factors in premenopausal breast cancer risk. Breast Cancer Res Treat 1998;47:111–20

    Article  PubMed  Google Scholar 

  30. Goodwin PJ, Ennis M, Pritchard KI, Trudeau ME, Koo J, Madarnas Y, Hartwick W, Hoffman B, Hood N. Fasting insulin and outcome in early-stage breast cancer: results of a prospective cohort study. J Clin Oncol 2002;20:42–51

    Article  PubMed  CAS  Google Scholar 

  31. Milazzo G, Giorgino F, Damante G, Sung C, Stampfer MR, Vigneri R, Goldfine ID, Belfiore A. Insulin receptor expression and function in human breast cancer cell lines. Cancer Res 1992;52:3924–30

    PubMed  CAS  Google Scholar 

  32. Kaleko M, Rutter WJ, Miller AD. Overexpression of human insulin like growth factor I receptor promotes ligand-dependent neoplastic transformation. Mol Cell Biol 1990;10:464–73

    PubMed  CAS  Google Scholar 

  33. Gavrila A, Chan JL, Yiannakouris N, Kontogianni M, Miller LC, Orlova C, Mantzoros CS. Serum adiponectin levels are inversely associated with overall and central fat distribution but are not directly regulated by acute fasting or leptin administration in humans: cross-sectional and interventional studies. J Clin Endocrinol Metab 2003;88:4823–31

    Article  PubMed  CAS  Google Scholar 

  34. Okumura M, Yamamoto M, Sakuma T, Kojima T, Maruyama M, Jamali M, Cooper DR, Yasuda K. Leptin and high glucose stimulate cell proliferation in MCF-7 human breast cancer cells: reciprocal involvement of PKC-α and PPAR expression. Biochim Biophys Acta 2002;1592:107–16

    PubMed  CAS  Google Scholar 

  35. Matsubara M, Maruoka S, Katayose S. Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women. Eur J Endocrinol 2002;147:173–80

    Article  PubMed  CAS  Google Scholar 

  36. Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y, Iwahashi H, Kuriyama H, Ouchi N, Maeda K, Nishida M, Kihara S, Sakai N, Nakajima T, Hasegawa K, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita S, Hanafusa T, Matsuzawa Y. Plasma concentrations of a novel, adipose-specific protein, adiponectin, type 2 diabetic patients. Arterioscler Thromb Vasc Biol 2000;20:1595–9

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Internal Medicine, Etimesgut Military Hospital, Ankara, Turkey

    Mehmet Karaduman & Ahmet Bilici

  2. Department of Medical Oncology, Gulhane Military School of Medicine, Ankara, Turkey

    Ahmet Ozet

  3. Department of Immunology, Gulhane Military School of Medicine, Ankara, Turkey

    Ali Sengul & Ugur Musabak

  4. Department of Pathology, Diyarbakir Military Hospital, Diyarbakir, Turkey

    Melih Alomeroglu

  5. Kur Sitesi, 46495 ADA, D1B-2/B Blok, No:1, 5.Etap, Eryaman, Ankara, Turkey

    Ahmet Bilici

Authors
  1. Mehmet Karaduman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ahmet Bilici
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ahmet Ozet
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ali Sengul
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ugur Musabak
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Melih Alomeroglu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ahmet Bilici.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Karaduman, M., Bilici, A., Ozet, A. et al. Tissue levels of adiponectin in breast cancer patients. Med Oncol 24, 361–366 (2007). https://doi.org/10.1007/s12032-007-0021-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12032-007-0021-0

Keywords

Search

Navigation