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Association Between the Change of Serum Copper and Ischemic Stroke: a Systematic Review and Meta-Analysis

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Abstract

Ischemic stroke is the most common stroke subtypes with all strokes. More and more studies found that serum copper was related to the ischemic stroke. However, the correlation between serum copper and ischemic stroke was inconsistent. We performed the meta-analysis to assess the association between the change of serum copper and ischemic stroke. Electronic databases were identified to search for relevant studies about serum copper and ischemic stroke from inception to February 28, 2019. Eight studies with a total of 777 participants were included into this meta-analysis. Because of high heterogeneity (I2 = 71%), we chose a random effect model. Our results showed the serum copper levels were significantly higher in ischemic stroke group compared with controls group (pooled mean difference, 1.25; 95% confidence intervals (CIs), 0.07–2.43; P = 0.04), in particular studies after the year of 2009 (I2 = 0%; pooled mean difference, 2.16; 95% CI, 1.37–2.95; P < 0.00001). Serum copper was associated with ischemic stroke, and it may be one of the risk factors of ischemic stroke.

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Funding

The research was supported by the program for tackling key problems in science and technology for social development. It is a program project with science and technology research and development of Shaanxi Province, China (Grant No. S2015YFSF0325).

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Authors and Affiliations

  1. Xi’an Medical University, No. 74 Hanguangbei Road, Xi’an, 710068, Shaanxi, China

    Mijuan Zhang, Yan Wang, Minjiang Ma & Chune Tian

  2. Department of Neurology, Shaanxi Provincial People’s Hospital, No. 256 Youyixi Road, Xi’an, 710068, Shaanxi, China

    Wei Li & Tao Wang

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  1. Mijuan Zhang
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  2. Wei Li
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  3. Yan Wang
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  4. Tao Wang
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  5. Minjiang Ma
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  6. Chune Tian
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Correspondence to Wei Li.

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Zhang, M., Li, W., Wang, Y. et al. Association Between the Change of Serum Copper and Ischemic Stroke: a Systematic Review and Meta-Analysis. J Mol Neurosci 70, 475–480 (2020). https://doi.org/10.1007/s12031-019-01441-6

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  • DOI: https://doi.org/10.1007/s12031-019-01441-6

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