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Association Between Cystatin C and the Risk of Ischemic Stroke: a Systematic Review and Meta-analysis

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Abstract

Ischemic stroke is a disease that affects people’s health and quality of life. Cystatin C has been found as a new biomarker of cardiovascular disease. We performed this meta-analysis to assess the relationship between cystatin C and the risk of ischemic stroke. The studies on looking at the association between cystatin C and ischemic stroke were identified from inception to November 18, 2018. We performed a random-effects meta-analysis using mean difference. Nine studies with a total of 3773 ischemic stroke patients were included into the meta-analysis. Our results showed that patients with ischemic stroke had significantly higher serum cystatin C concentrations compared with the participants without ischemic stroke (pooled mean difference, 0.11; 95% confidence interval (CI), 0.00–0.22; P = 0.04), in particular acute ischemic stroke and subclinical cerebral infarction (mean difference, 0.23; 95% CI, 0.11–0.36; P = 0.0003 and mean difference, 0.07; 95% CI, 0.05–0.09; P < 0.00001, respectively). Cystatin C was associated with ischemic stroke, and it could be considered a predictor for the risk of ischemic stroke, especially in acute ischemic stroke and subclinical cerebral infarction.

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Funding

This work was supported by the program for tackling key problems in science and technology for social development. It is a program project with science and technology research and development of Shaanxi province, China (Grant No.S2015YFSF0325).

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Authors and Affiliations

  1. Xi’an Medical University, No 74 Hanguangbei Road, Xi’an, 710068, Shaanxi, China

    Yan Wang, Mijuan Zhang, Chun’e Tian, Minjiang Ma & Qian Zhang

  2. Department of Neurology, Shaanxi Provincial People’s Hospital, No 256 Youyixi Road, Xi’an, 710068, Shaanxi, China

    Wei Li, Jun Yang, Mijuan Zhang, Chun’e Tian & Minjiang Ma

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  1. Yan Wang
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  2. Wei Li
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Correspondence to Wei Li.

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Wang, Y., Li, W., Yang, J. et al. Association Between Cystatin C and the Risk of Ischemic Stroke: a Systematic Review and Meta-analysis. J Mol Neurosci 69, 444–449 (2019). https://doi.org/10.1007/s12031-019-01373-1

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