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Association Between TRAF6 Gene Polymorphisms and Susceptibility of Ischemic Stroke in Southern Chinese Han Population

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Abstract

The tumor necrosis factor receptor-associated factor 6 (TRAF6) gene encodes a protein that acts downstream of the Toll-like receptor (TLR) pathway. TLRs activate inflammatory cascades and mediate inflammatory injury after cerebral ischemia. However, the role of TFAR6 gene polymorphisms in ischemic stroke (IS) remains unknown. This study aims to investigate the associations of TRAF6 gene polymorphisms with susceptibility to IS and IS-related quantitative traits in Southern Chinese Han population. A total of 816 IS cases and 816 age- and gender-matched controls were included. Two variants of the TRAF6 gene (rs5030411 and rs5030416) were genotyped using the Sequenom MassARRAY iPLEX platform. Our study showed that rs5030416 was significantly associated with increased susceptibility to IS in the additive model [ORadj 1.25(1.04–1.51), P adj = 0.019, P Bc = 0.038] and dominant model [ORadj 1.23(1.04–1.60), P adj = 0.021, P Bc = 0.042] after adjusting by age and sex and applying a Bonferroni correction. No significant association was found between rs5030411 and IS susceptibility (all P > 0.05). The haplotype rs5030416 (allele C)-rs5030411 (allele C) was significantly associated with IS susceptibility (P adj = 0.015). Moreover, a significant association of rs5030411 with TC levels in IS patients under the additive model [β 0.16(0.01–0.30), P adj = 0.034] and recessive model [β 0.45(0.12–0.78), P adj = 0.007] was observed after adjustment by age and sex. This association remained statistically significant under the recessive model (P Bc = 0.042) after Bonferroni correction. Our results suggest that TRAF6 gene polymorphisms may be involved in the pathogenesis of IS.

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Acknowledgments

Our study is supported by grants from the National Natural Science Foundation of China (Grant Nos. 81473670 and 81260594), the Guangxi National Natural Science Foundation (Grant No. 2013GXNSFAA019145), and the Scientific Research Foundation of the Guangxi Health Department (Grant No. 2012047).

Conflict of Interest

None declared.

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Authors and Affiliations

  1. School of Public Health, Guangxi Medical University, Nanning, Guangxi, China

    Li Su

  2. First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China

    Ziwen Chen, Yan Yan, Baoyun Liang, Juanjuan Xie, Qing Chen, Jinjing Tan & Lian Gu

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  1. Li Su
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  2. Ziwen Chen
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  3. Yan Yan
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  4. Baoyun Liang
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  5. Juanjuan Xie
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  6. Qing Chen
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  7. Jinjing Tan
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  8. Lian Gu
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Correspondence to Lian Gu.

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Li Su, Ziwen Chen, and Yan Yan were the first coauthors.

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Su, L., Chen, Z., Yan, Y. et al. Association Between TRAF6 Gene Polymorphisms and Susceptibility of Ischemic Stroke in Southern Chinese Han Population. J Mol Neurosci 57, 386–392 (2015). https://doi.org/10.1007/s12031-015-0580-z

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  • DOI: https://doi.org/10.1007/s12031-015-0580-z

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