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Delayed Effect of the Light Pulse on Phosphorylated ERK1/2 and GSK3β Kinases in the Ventrolateral Suprachiasmatic Nucleus of Rat

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Abstract

The intrinsic period of circadian clock in the suprachiasmatic nucleus is entrained to a 24-h cycle by external cues, mainly light. Previous studies have shown that light applied at night induces robust phosphorylation of extracellular-signal-regulated kinase that is necessary to process the light pulse into the phase shift of the clock phase. In this study, we show the persistent downregulation of phosphorylated extracellular-signal-regulated kinase and transient downregulation of phosphorylated glycogen synthase kinase-3beta in the ventrolateral part of the suprachiasmatic nucleus to photic stimuli starting at 2 h after the beginning of the light pulse. As both kinases are involved in regulation of circadian clockwork, we hypothesize that these changes may contribute to the phase-shifting effect of light at night.

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Acknowledgments

This work was supported by the Czech Science Foundation (P303/12/1137) and the Ministry of Education, Youth and Sport of the Czech Republic (SVV-260087/2014).

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Authors and Affiliations

  1. Department of Physiology, Faculty of Science, Charles University in Prague, Viničná 7, Prague 2, 128 43, Czech Republic

    Kateřina Červená, Dominika Pačesová, Veronika Spišská & Zdeňka Bendová

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  1. Kateřina Červená
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  2. Dominika Pačesová
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  3. Veronika Spišská
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  4. Zdeňka Bendová
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Correspondence to Zdeňka Bendová.

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Červená, K., Pačesová, D., Spišská, V. et al. Delayed Effect of the Light Pulse on Phosphorylated ERK1/2 and GSK3β Kinases in the Ventrolateral Suprachiasmatic Nucleus of Rat. J Mol Neurosci 56, 371–376 (2015). https://doi.org/10.1007/s12031-015-0563-0

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  • DOI: https://doi.org/10.1007/s12031-015-0563-0

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