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Chemotactic Responses of Neural Stem Cells to SDF-1α Correlate Closely with Their Differentiation Status

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Abstract

Chemotaxis of neural stem/progenitor cells (NSCs) is regulated by a variety of factors, and much effort has been devoted to the delineation of factors that are involved in NSC migration. However, the relationship between NSC chemotactic migration and differentiation remains uncharacterized. In the present study, by comparing the transfilter migration rate, single-cell migration speed, and directional efficiency of NSCs in stromal cell-derived factor-1 alpha (SDF-1α)-induced Boyden chamber and Dunn chamber chemotaxis assays, we demonstrate that NSCs in varying differentiation stages possess different migratory capacity. Furthermore, F-actin microfilament reorganization upon stimulation varies greatly among separate differentiation states. We show that signaling pathways involved in NSC migration, such as PI3K/Akt and mitogen-activated protein kinase (MAPK) (ERK1/2, JNK, and p38 MAPK) pathways, are differentially activated by SDF-1α among each NSC differentiation stages, and the extent to which these pathways participate in cell chemotaxis exhibits a differentiation stage-dependent manner. Taken together, these results suggest that the differentiation of NSCs influences their chemotactic responses to SDF-1α, providing new insight into the optimization of the therapeutic efficacy of NSCs for neural regeneration and nerve repair after injury.

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Acknowledgments

We thank Dr. Evan Snyder for providing the C17.2 cell line. This work was supported by the National Natural Science Foundation of China (Nos. 31371407 and 31071220).

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  1. Department of Cell Biology, Jiangsu Key Laboratory of Stem Cell Research, Medical College of Soochow University, Ren Ai Road 199, Suzhou Industrial Park, Suzhou, 215123, China

    Yebing Chen, Youhua Wei, Jing Liu & Huanxiang Zhang

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  1. Yebing Chen
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  2. Youhua Wei
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Chen, Y., Wei, Y., Liu, J. et al. Chemotactic Responses of Neural Stem Cells to SDF-1α Correlate Closely with Their Differentiation Status. J Mol Neurosci 54, 219–233 (2014). https://doi.org/10.1007/s12031-014-0279-6

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