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Interkinetic Nuclear Movement in the Ventricular Zone of the Cortex

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Abstract

The nuclei of neuroepithelial cells move along the apicobasal axis in synchronization with their cell cycle status. This motility is known as interkinetic nuclear movement. We discuss here the importance of cytoskeleton organization, the centrosome, molecular motors, cell polarity proteins, and their regulators in controlling and maintaining this typical behavior. Furthermore, due to the tight linkage between cell proliferation, cell cycle, and nuclear motility, we speculate that interkinetic nuclear movement is likely to be affected in the pathophysiology of microcephaly, where the brain size is markedly reduced.

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Acknowledgments

We thank the current and previous lab members for their contributions. O.R. is an incumbent of the Berstein-Mason professorial chair of Neurochemistry. Our research has been supported in part by the Israel Science Foundation (grant no. 47/10), BSF grant 2007081, the Legacy Heritage Biomedical Program of the Israel Science Foundation (grant no. 1062/08), Minerva foundation with funding from the Federal German Ministry for Education and Research, ERANET-NEURON (DISCover, IMOS 3-00000-6785), the Benoziyo Center for Neurological diseases, the Helen and Martin Kimmel Stem Cell Research Institute, and the David and Fela Shapell Family Center for Genetic Disorders Research.

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  1. Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel

    Orly Reiner, Tamar Sapir & Gabi Gerlitz

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  1. Orly Reiner
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Correspondence to Orly Reiner.

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Reiner, O., Sapir, T. & Gerlitz, G. Interkinetic Nuclear Movement in the Ventricular Zone of the Cortex. J Mol Neurosci 46, 516–526 (2012). https://doi.org/10.1007/s12031-011-9633-0

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