Abstract
It was previously demonstrated that secretin influenced the behavior of rats investigated by open-field test. In the present experiment, we have compared the effect of intracerebroventricular administration of 2 μg of secretin on the behavior of CFLP white and Japanese waltzing mice. These latter animals exhibit stereotypic circular movements. The effect of secretin on the horizontal (ambulation) and vertical movements (rearing and jumping) was investigated in open-field test. The ambulation time and distance were shorter, and the number of rearing and jumping were much lower in Japanese waltzing mice than in CFLP white mice during 30 min-experimental period. In white mice, 2 μg of secretin had no effect on the above-mentioned parameters; however, in Japanese waltzing mice, secretin enhanced the ambulation time and distance to the level of CFLP white mice, but did not influence the rearing and jumping. On the basis of the results, it was concluded that intracerebroventricularly administered secretin attenuated the stereotypic (circulating) movement and improved the horizontal movement indicated by the normalization of the ambulation time and distance; however, it did not influence the explorative behavior (rearing and jumping) in our special animal model.
Similar content being viewed by others
References
Babarczy E, Szabó G, Telegdy G (1995) Effects of secretin on acute and chronic effects of morphine. Pharmacol Biochem Behav 51:469–472
Bayliss WM, Starling EH (1902) The mechanism of pancreatic secretion. J Physiol 28:325–353
Carty ML, Wixey JA, Kesby J, Reinebrant HE, Colditz PB, Gobe G, Buller KM (2010) Long-term losses of amygdala corticotropin-releasing factor neurons are associated with behavioural outcomes following neonatal hypoxia-ischemia. Behav Brain Res 208:609–18
Charlton CG, O’Donohue TL, Miller RL, Jakobowitz DM (1981) Secretin immunoreactivity in rat and pig brain. Peptides 2:45–49
Charlton CG, Miller RL, Crawley JN, Handelmann GE, O’Donohue TL (1983) Secretin modulation of behavioral and physiological functions in the rat. Peptides 4:739–742
Chu JY, Lee LT, Lai CH, Vaudry H, Chan YS, Yung WH, Chow BK (2009) Secretin as a neurohypophysial factor regulating body water homeostasis. Proc Natl Acad Sci USA 106:15961–6
Davis M, Whalen P (2001) The amygdala: vigilance and emotion. Mol Psychiatry 6:13–34
Goulet M, Shiromani PJ, Ware CM, Strong RA, Boismenu R, Rusche A (2003) Secretin i.v. infusion activates gene expression in the central amygdala of rats. Neuroscience 118:881–8
Hammack SE, Guo J-D, Hazra R, Dabrowska J, Myers KM, Rainnie DG (2009) The response of neurons in the bed nucleus of the stria terminalis to serotonin: implications for anxiety. Prog Neuro-Psycho Biol Psych 33:1309–20
Itoh N, Furuya T, Ozaki K, Ohta M, Kawasaki T (1991) The secretin precursor gene. Structure of the coding region and expression in the brain. J Biol Chem 266:12595–8
Jaton AL, Vigouret JM, Dravid A (1981) Involvement of serotoninergic mechanisms in the circling behaviour induced by apomorphine and LSD 25 in rats. J Physiol Paris 77:405–11
Jorpes JE, Mutt V, Magnusson S, Steele BB (1962) Amino acid composition and en-terminal amino acid sequence of porcine secretin. BBRC 9:275–9
Kim HS, Yumkham S, Kim SH, Yea K, Shin YC, Ryu SH, Suh PG (2006) Secretin induced neurite outgrowth of PC12 through cAMP—mitogen-activated protein kinase pathway. Exp Mol Med 38:85–93
Köves K, Kausz M, Reser D, Horváth K (2002) What may be the anatomical basis that secretin can improve the mental functions in autism? Regul Pept 109:167–172
Köves K, Kausz M, Reser D et al (2004) Secretin and autism: a basic morphological study about the distribution of secretin in the nervous system. Regul Pept 123:209–216
Kuntz A, Clement HW, Lehnert W, Van Calker D, Hennighausen K, Gerlach M, Schulz E (2004) Effects of secretin on extracellular amino acid concentrations in rat hippocampus. J Neural Trans 111:931–939
Pierce K, Courchesne E (2001) Evidence for a cerebellar role in reduced exploration and sterotyped behavior in autism. Biol Psychiatry 49:655–664
Pycock CJ, Marsden CD (1978) The rotating rodent: a two component system? Eur J Pharmacol 47:167–75
Roskoski R Jr, White L, Knowlton R, Roskoski LM (1989) Regulation of thyrosine hydroxylase activity in rat PC12 cells by neuropeptides of the secretin family. Mol Pharmacol 36:925–31
Walker DL, Miles LA, Davis M (2009) Selective participation of the bed nucleus of stria terminalis and CRF in sustained anxiety-like versus phasic fear-like responses. Prog Neuro-Psychopharmacol Biol Psychiatry 33:1291–1308
Welch MG, Ruggiero DA (2005) Predicted role of secretin and oxytocin in the treatment of behavioral and developmental disorders: implication for autism. Int Rev Neurobiol 71:273–315
Welch MG, Keune JD, Welch-Horan TB, Anwar N, Anwar M, Ruggiero DA (2003) Secretin activates visceral brain regions in the rat including areas abnormal in autism. Cell Mol Neurobiol 23:817–37
Welch MG, Keune JD, Welch-Horan TB, Anwar N, Anwar M, Ludwig RJ, Ruggiero DA (2004) Secretin: hypothalamic distribution and hypothesized neuroregulatory role in autism. Cell Mol Neurobiol 24:219–241
Yamagata T, Urano H, Weeber EJ, Nelson DL, Nishijima I (2008) Impaired hippocampal synaptic function in secretin-deficient mice. Neuroscience 154:1417–1422
Yung WH, Leung PS, Ng SSM, Zhang J, Chan SCY, Chow BKC (2001) Secretin facilitates GABA transmission in the cerebellum. J Neurosci 21:7063–7068
Yung WH, Chan YS, Chow BK, Wang JJ (2006) The role of secretin in the cerebellum. Cerebellum 5:43–8
Acknowledgment
This work was partially supported by the Department of Human Morphology and Developmental Biology, Semmelweis University and ETT-Grant (355-08) to Gyula Szabó. We say thanks to Anna Takács for her technical assistance.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Köves, K., Kiss, G., Heinzlmann, A. et al. Secretin Attenuates the Hereditary Repetitive Hyperactive Movements in a Mouse Model. J Mol Neurosci 43, 109–114 (2011). https://doi.org/10.1007/s12031-010-9408-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12031-010-9408-z