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Genetic Polymorphism of Glutathione S-transferase T1 (GSTT1) and QT-Interval in Schizophrenia Patients

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Abstract

Several antipsychotic agents are known to prolong the QT interval in a dose-dependent manner. The antipsychotic drugs are substrates of the phase I of biotransformation enzymes of cytochrome P450. In order to find the possible influence of polymorphism of GSTT1 (a member of class theta glutathione S-transferase) on rate-corrected QT interval (QTc) of schizophrenia patients, the present study was done. Forty-three schizophrenia in-patients participated in the study. The patients were diagnosed as chronic schizophrenia according to structured clinical interview using SCID-I (clinician version) to confirm and document DSM-IV diagnosis. Measurements of QT and RR intervals were recorded using a magnifying grid on lead II. The QTc was calculated according to Bazett’s formula. Polymerase chain reaction-based method was used in order to determine the GSTT1 genotypes. Based on the fitted model of multiple linear regression analysis, QTc decreased in persons with positive GSTT1 genotype in comparison with the null genotype (β = −0.328, t = −2.346, p = 0.024). Active genotype of GSTT1 decreased the QTc. Also, QTc was significantly associated with smoking status; it was decreased in smokers compared with nonsmokers (β = −0.372, t = −2.372, p = 0.014).

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Acknowledgements

The authors are indebted to the participants for their close cooperation. The authors are indebted to Dr. Maryam Ansari-Lari for critical reading of the manuscript and for her contribution in discussion. Also, we would like to acknowledge Mrs. Fatemeh Mobayen for her assistance during the course of this study. This study was supported by Shiraz University.

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Authors and Affiliations

  1. Department of Biology, College of Sciences, Shiraz University, Shiraz, 71454, Iran

    Aminollah Bahaoddini & Mostafa Saadat

  2. Institute of Biotechnology, Shiraz University, Shiraz, Iran

    Aminollah Bahaoddini & Mostafa Saadat

  3. Department of Psychiatry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

    Hassan Farrashbandi

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  1. Aminollah Bahaoddini
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  2. Hassan Farrashbandi
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  3. Mostafa Saadat
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Correspondence to Mostafa Saadat.

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Bahaoddini, A., Farrashbandi, H. & Saadat, M. Genetic Polymorphism of Glutathione S-transferase T1 (GSTT1) and QT-Interval in Schizophrenia Patients. J Mol Neurosci 38, 173–177 (2009). https://doi.org/10.1007/s12031-008-9160-9

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  • DOI: https://doi.org/10.1007/s12031-008-9160-9

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