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Insulin-like Growth Factor System Regulates Oligodendroglial Cell Behavior: Therapeutic Potential in CNS

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Abstract

Amongst the many soluble extracellular factors stimulating intracellular signal transduction pathways and driving cellular processes such as proliferation, differentiation and survival, insulin-like growth factors (IGFs) stand out as indispensable factors for proper oligodendrocyte differentiation and accompanying myelin production. Owing to its potent myelinogenic capacity and its neuroprotective properties, IGFs hold therapeutic potential in demyelinating and neurodengenerative diseases. However, the IGF system is comprised of a complex molecular network involving regulatory binding proteins, proteases, cell surface and extracellular matrix components which orchestrate IGF-specific functions. Thus, the complexity by which these factors are tightly regulated makes a simplistic therapeutic approach towards treating demyelinating conditions unfeasible. In the present review, we address these issues and consider current therapeutic prospects of oligodendrocyte-targeted IGF-based therapies.

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Acknowledgements

Daniel Chesik is a recipient of a grant from the Dutch foundation Stichting Multiple Sclerose Anders to which authors are indebted for supporting studies concerning insuline-like growth factor therapeutic potential in treating multiple sclerosis.

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  1. Department of Neurology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands

    Daniel Chesik, Jacques De Keyser & Nadine Wilczak

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  1. Daniel Chesik
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Correspondence to Daniel Chesik.

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Chesik, D., De Keyser, J. & Wilczak, N. Insulin-like Growth Factor System Regulates Oligodendroglial Cell Behavior: Therapeutic Potential in CNS. J Mol Neurosci 35, 81–90 (2008). https://doi.org/10.1007/s12031-008-9041-2

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