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Epidemiology of Gastric Cancer in North Africa and the Middle East from 1990 to 2017

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Abstract

Introduction

Gastric cancer is the fifth most common cancer worldwide and the third cause of cancer deaths and disability-adjusted life years (DALYs) worldwide. The countries of the Middle East and North Africa are similar in many determinants of health, but there are significant differences in the incidence of gastric cancer in these countries. Therefore, the purpose of this study was to compare the burden of gastric cancer in MENA countries with appropriate policies to reduce the incidence and mortality of gastric cancer in the region.

Materials and Methods

GBD database data were used to assess the gastric cancer indices in MENA countries consisted of 21 countries in the Middle East and North Africa in 1900 and 2017. Gastric cancer–related analysis using DALY counts, which is the sum of YLLs (total years lost due to premature death) and YLDs (years lost due to disability), and incidence rates, prevalence rates, death rates, and standardized age rates (ASR) were measured.

Results

The incidence of gastric cancer has decreased in the world and the MENA region from 1990 to 2017, which is higher than the global average in MENA. But death rates in the region have decreased below the global average. The trend of changes in DALY count has increased from 1990 to 2017 in all countries in the region except Turkey. This increase is higher in men than in women and also in Iran. In these countries, the highest percentage of total DALY of gastric cancer is attributable to the risk factors for high sodium and cigarette consumption, in Turkey and the United Arab Emirates, respectively (from 1990 to 2017) Also, the largest decrease is in the UAE and Iraq, respectively.

Conclusion

Despite a decrease in the incidence of gastric cancer and, possibly, due to late diagnosis and poor health services, the attenuation of gastric cancer is high in MENA countries. Therefore, it is recommended to reduce the attenuation of screening programs before 50 years old for early detection in addition to prevention programs and to reduce smoking, especially in men.

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References

  1. Dhillon PK, Mathur P, Nandakumar A, Fitzmaurice C, Kumar GA, Mehrotra R, et al. The burden of cancers and their variations across the states of India: the global burden of disease study 1990–2016. Lancet Oncol. 2018;19(10):1289–306.

    Article  Google Scholar 

  2. Organization WH. Cancer burden rise to 18.1 million new cases and 9.6 million cancer deaths in 2018; 2019.

  3. Braga LLBC, Ramos AN, Neto MBB, Ferreira AF, Queiroz DMM, Maia DCC, et al. Unequal burden of mortality from gastric cancer in Brazil and its regions, 2000–2015. Gastric Cancer. 2019;22(4):675–83.

    Article  Google Scholar 

  4. Jenabi E, Saatchi M, Khazaei S, Mansori K, Ayubi E, Soheylizad M, et al. National distribution of stomach cancer incidence in Iran: a population-based study. Adv Hum Biol. 2019;9(1):89.

  5. Rawla P, Sunkara T, Barsouk A. Epidemiology of colorectal cancer: Incidence, mortality, survival, and risk factors. Prz Gastroenterol. 2019;14(2):89.

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Sitarz R, Skierucha M, Mielko J, Offerhaus GJA, Maciejewski R, Polkowski WP. Gastric cancer: epidemiology, prevention, classification, and treatment. Cancer Manag Res. 2018;10:239–48.

    Article  CAS  Google Scholar 

  7. Casamayor M, Morlock R, Maeda H, Ajani J. Targeted literature review of the global burden of gastric cancer. Ecancermedicalscience. 2018;12. https://doi.org/10.3332/ecancer.2018.883.

  8. Nagini S. Carcinoma of the stomach: a review of epidemiology, pathogenesis, molecular genetics and chemoprevention. World J Gastrointest Oncol. 2012;4(7):156–69.

    Article  Google Scholar 

  9. Ruiz EF, Torres-Roman JS, Servan SA, Martinez-Herrera JF, Arce-Huamani MA, Carioli G, et al. Trends and geographic pattern of stomach cancer mortality in Peru. Cancer Epidemiol. 2019;58:193–8.

    Article  Google Scholar 

  10. Ostovar R, Eghdami A, Jafari A, Ravangard R. Burden of gastric cancer: a case study of Iran. World Family Medicine Journal: Incorporating the Middle East J Fam Med. 2018;99(5897):1–5.

  11. Harris RE. Epidemiology of chronic disease: global perspectives. Jones & Bartlett Learning; 2019.

  12. Eghdami A, Ostovar R, Jafari A, Palmer AJ, Bordbar N, Ravangard R. Economic burden of gastric cancer: a case of Iran. Cancer Control. 2019;26(1):1073274819837185.

    Article  Google Scholar 

  13. Saadatifar H, Ostadimoghaddam H, Khoshhal F, Jabbari-Azad F, Mohazzab-Torabi S, Yekta A, et al. The prevalence of obesity and overweight in Northeastern Iran. Asian J Health Sci. 2018;4(1):1–10.

  14. Sepanlou SG, Malekzadeh F, Delavari F, Naghavi M, Forouzanfar MH, Moradi-Lakeh M, et al. Burden of gastrointestinal and liver diseases in Middle East and North Africa: results of global burden of diseases study from 1990 to 2010. Middle East J Dig Dis. 2015;7(4):201.

    PubMed  PubMed Central  Google Scholar 

  15. Etemadi A, Safiri S, Sepanlou SG, Ikuta K, Bisignano C, Shakeri R, et al. The global, regional, and national burden of stomach cancer in 195 countries, 1990–2017: a systematic analysis for the global burden of disease study 2017. Lancet Gastroenterol Hepatol. 2020;5(1):42–54.

    Article  Google Scholar 

  16. Fitzmaurice C, Akinyemiju TF, Al Lami FH, Alam T, Alizadeh-Navaei R, Allen C, et al. Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 29 cancer groups, 1990 to 2016: a systematic analysis for the global burden of disease study. JAMA Oncol. 2018;4(11):1553–68.

    Article  Google Scholar 

  17. Vos T, Abajobir AA, Abate KH, Abbafati C, Abbas KM, Abd-Allah F, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the global burden of disease study 2016. Lancet. 2017;390(10100):1211–59.

    Article  Google Scholar 

  18. Ahmad OB, Boschi-Pinto C, Lopez AD, Murray CJ, Lozano R, Inoue M. Age standardization of rates: a new WHO standard. Geneva: World Health Organization; 2001;9(10).

  19. Porta M. A dictionary of epidemiology. Oxford university press; 2014.

  20. Pourhoseingholi MA, Vahedi M, Baghestani AR. Burden of gastrointestinal cancer in Asia; an overview. Gastroenterol Hepatol Bed Bench. 2015;8(1):19–27.

    PubMed  PubMed Central  Google Scholar 

  21. Farhood B, Geraily G, Alizadeh A. Incidence and mortality of various cancers in Iran and compare to other countries: a review article. Iran J Public Health. 2018;47(3):309–16.

    PubMed  PubMed Central  Google Scholar 

  22. Collaborators GEMRC. Burden of cancer in the eastern Mediterranean region, 2005–2015: findings from the global burden of disease 2015 study. Int J Public Health. 2018;63(1):151–64.

    Google Scholar 

  23. Kamineni A, Williams MA, Schwartz SM, Cook LS, Weiss NS. The incidence of gastric carcinoma in Asian migrants to the United States and their descendants. Cancer Causes Control. 1999;10(1):77–83.

    Article  CAS  Google Scholar 

  24. Charafeddine MA, Olson SH, Mukherji D, Temraz SN, Abou-Alfa GK, Shamseddine AI. Proportion of cancer in a middle eastern country attributable to established risk factors. BMC Cancer. 2017;17(1):337.

    Article  Google Scholar 

  25. Rastaghi S, Jafari-Koshki T, Mahaki B, Bashiri Y, Mehrabani K, Soleimani A. Trends and risk factors of gastric cancer in Iran (2005–2010). Int J Prev Med. 2019;10.

  26. Yalcin S. Gastric cancer in Turkey—a bridge between west and east. Gastrointest Cancer Res. 2009;3(1):29–32.

    PubMed  PubMed Central  Google Scholar 

  27. Leung WK, Wu M-s, Kakugawa Y, Kim JJ, Yeoh K-g, Goh KL, et al. Screening for gastric cancer in Asia: current evidence and practice. Lancet Oncol. 2008;9(3):279–87.

    Article  Google Scholar 

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Funding

This study was funded by Kermanshah University of Medical Sciences.

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Authors and Affiliations

  1. Behavioral Disease Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Yousef Ramazani, Ehsan Mardani & Mahin Amini

  2. Research Center for Environmental Determinants of Health, School of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Farid Najafi & Mahdi Moradinazar

Authors
  1. Yousef Ramazani
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  2. Ehsan Mardani
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  3. Farid Najafi
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  4. Mahdi Moradinazar
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  5. Mahin Amini
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Corresponding author

Correspondence to Mahin Amini.

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The authors declare that they have no conflict of interest.

Ethics Approval and Consent to Participate

The study was approved by research ethics committee of Kermanshah University of medical sciences.

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All the authors and the Kermanshah University of Medical Sciences consented to publish the study in your Journal.

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Ramazani, Y., Mardani, E., Najafi, F. et al. Epidemiology of Gastric Cancer in North Africa and the Middle East from 1990 to 2017. J Gastrointest Canc 52, 1046–1053 (2021). https://doi.org/10.1007/s12029-020-00533-6

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  • DOI: https://doi.org/10.1007/s12029-020-00533-6

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