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Liposarcoma of Hypopharynx and Esophagus: a Unique Entity?

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Abstract

Purpose

Liposarcoma is the most common soft tissue sarcoma in adults. It represents approximately 20 % of all mesenchymal malignancies. It most frequently involves retroperitoneum, trunk, and extremities. Hypopharyngeal and esophageal localization of liposarcoma is extremely rare.

Methods

We performed a systematic review of literature and reported 26 and 33 cases of hypopharyngeal and esophageal liposarcoma. We analyzed natural history, imaging features, histology, treatment, and prognosis, with a specific focus to similarities and differences between tumors of hypopharynx and esophagus.

Results

Hypopharyngeal and esophageal liposarcomas have more similarities than differences. Incidence has a peak at 6th and 7th decades. The diagnostic procedures are barium swallow, endoscopic examination, and CT/MR imaging. Well-differentiated liposarcoma represents the most frequent histological subtype. Surgical excision is the main treatment. Endoscopic resection can be useful for pedunculated tumors of hypopharynx and cervical esophagus. Differences between hypopharyngeal and esophageal liposarcoma are represented by local recurrence rate (greater for hypopharyngeal tumors), number of giant tumors, and time to recurrence (greater for esophageal tumors). Finally, liposarcomas of distal esophagus need more extended approaches.

Conclusions

Liposarcomas of hypopharynx and cervical esophagus could be considered a unique pathological entity, with similar features and treatment options. Survival rate is dependent on histological type and location. Local recurrence is common, especially for hypopharyngeal liposarcoma, while the risk of lymph node or distant metastasis is very low. Patients should undergo regular examinations to rule out local recurrence, also for a long time, especially for esophageal tumors.

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References

  1. Srivastava A, Ghosh A, Saha S, Saha VP, Chakraborty D. Sarcomas of head and neck. A 10 years experience. Indian J Otolaryngol Head Neck Surg. 2007;59:322–6.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Gritli S, Khamassi K, Lachkhem A, Touati S, Chorfa A, Ben Makhlouf T, et al. Head and neck liposarcomas: a 32 years experience. Auris Nasus Larynx. 2010;37(3):347–51.

    Article  PubMed  Google Scholar 

  3. Mansour KA, Fritz RC, Jacobs DM, Vellios F. Pedunculated liposarcoma of the esophagus: a first case report. J Thorac Cardiovasc Surg. 1983;86:447–50.

    CAS  PubMed  Google Scholar 

  4. Frey-Schottman ML, Stiens R. Liposarkom im Hypopharynxbereich. Arch Ohren Nasen Kehlkopfheikd. 1979;223:419–22.

    Article  Google Scholar 

  5. Nofal F, Thomas M. Liposarcoma in the pharynx. J Laryngol Otol. 1989;103(11):1080–2.

    Article  CAS  PubMed  Google Scholar 

  6. Wenig BM, Weiss SW, Gnepp DR. Laryngeal and hypopharyngeal liposarcoma. Am J Surg Pathol. 1990;14(2):134–41.

    Article  CAS  PubMed  Google Scholar 

  7. Wenig BM, Heffner DK. Liposarcomas of the larynx and hypopharynx: a clinicopathologic study of eight new cases and a review of the literature. Laryngoscope. 1995;105:747–56.

    Article  CAS  PubMed  Google Scholar 

  8. Wambeek NDK, Mendelson RM. Liposarcoma of the hypopharynx. Australas Radiol. 1996;40:165–8.

    Article  CAS  PubMed  Google Scholar 

  9. Reed JM, Vick EG. Hypopharyngeal liposarcoma. Otolaryngol Head Neck Surg. 1996;114(3):499–500.

    Article  CAS  PubMed  Google Scholar 

  10. Fahmy FF, Osborne J, Khalil HS, Rodgers B. Well-differentiated liposarcoma of the hypopharynx. J Laryngol Otol. 1998;112:880–2.

    Article  CAS  PubMed  Google Scholar 

  11. Mandell DL, Brandwein MS, Woo P, Som PM, Biller HF, Urken ML. Upper aerodigestive tract liposarcoma: report on four cases and literature review. Laryngoscope. 1999;109:1245–52.

    Article  CAS  PubMed  Google Scholar 

  12. Mouret P. Liposarcoma of the hypopharynx. A case report and review of the literature. Rev Laryngol Otol Rhinol (Bord). 1999;120(1):39–42.

    CAS  Google Scholar 

  13. Almela Cortes R, Moreno Carazo A, Martin RL. Laryngeal and hypopharyngeal liposarcoma. Report of a case and literature review. An Otorrinolaringol Ibero Am. 2002;29(5):431–8.

    CAS  PubMed  Google Scholar 

  14. Sanz Gonzalo JJ, Martínez Molina P, Ribalta Farres MT, Sabater MF. Liposarcoma of the hypopharynx. Acta Otorrinolaringol Esp. 2002;53(1):60–3.

    Article  CAS  PubMed  Google Scholar 

  15. Gonzalez-Lois C, Ibarrola C, Ballestin C, Martanez-Tello FJ. Dedifferentiated liposarcoma of the pyriform sinus: report of a case and review of the literature. Int J Surg Pathol. 2002;10(1):75–9.

    Article  PubMed  Google Scholar 

  16. Cannizzaro MA, Cavallaro A, Veroux M, Costanzo M, Ferraù F, Veroux P. A case of pleomorphic liposarcoma involving a parahypopharyngeal site. Chir Ital. 2003;55(3):451–6.

    PubMed  Google Scholar 

  17. Luna-Ortiz K, Campos-Ramos E, Carmona-Luna T, Mohar-Betancourt A, Ferrari-Carballo T. Laser resection of liposarcoma of the hypopharynx. Med Oral Patol Oral Circ Bucal. 2009;14(5):E252–6.

    Google Scholar 

  18. Giordano G, Corcione L, Gnetti L, Mercante G, Ferri T. Dedifferentiated liposarcoma of the pyriform sinus. Oral Oncol Extra. 2006;42:176–80.

    Article  Google Scholar 

  19. McQueen C, Montgomery E, Dufour B, Olney MS, Illei PB. Giant hypopharyngeal atypical lipomatous tumor. Adv Anat Pathol. 2010;17(1):38–41.

    PubMed  Google Scholar 

  20. El Ouakif F, Decourselle F, Schultheis D. Liposarcoma of the hypopharynx: two case reports and literature review. Rev Laryngol Otol Rhinol (Bord). 2011;132(4–5):245–50.

    Google Scholar 

  21. Takano K, Kondoh A, Matsumiya H, Himi T. A well-differentiated liposarcoma of the hypopharynx. Otolaryngol Head Neck Surg. 2011;144(3):479–80.

    Article  PubMed  Google Scholar 

  22. Nouri H, Hassani R, Aderdour L, Raji A. The well-differentiated liposarcoma of the hypopharynx. Eur Ann Otorhinolaryngol Head Neck Dis. 2011;128(3):143–5.

    Article  CAS  PubMed  Google Scholar 

  23. Bergmark R, Jung D, Vakharia K, Gray ST, Lin DT, Rosenberg AE. Pathology quiz case 1. Liposarcoma of the hypopharynx. Arch Otolaryngol Head Neck Surg. 2012;138(3):313–5.

    Article  PubMed  Google Scholar 

  24. Bak YT, Kim JH, Kim JG, Lee CH, Lee KN, Choi YH, et al. Liposarcoma arising in a giant lipomatous polyp of the esophagus. Korean J Intern Med. 1989;4(1):86–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Yates SP, Collins MC. Case report: recurrent liposarcoma of the oesophagus. Clin Radiol. 1990;42(5):356–8.

    Article  CAS  PubMed  Google Scholar 

  26. Baca I, Klempa I, Weber JT. Liposarcoma of the esophagus. Eur J Surg Oncol. 1991;17(3):313–5.

    CAS  PubMed  Google Scholar 

  27. Masumori K, Yoshioka M, Tanaka Y, Uchida E, Higuchi K, Maeda S, et al. A case report of esophageal liposarcoma. Nihon Geka Gakkai Zasshi. 1991;92(7):885–8.

    CAS  PubMed  Google Scholar 

  28. Cooper GJ, Boucher NR, Smith JH, Thorpe JA. Liposarcoma of the esophagus. Ann Thorac Surg. 1991;51(6):1012–3.

    Article  CAS  PubMed  Google Scholar 

  29. Boggi U, Viacava P, Naccarato AG, Giulianotti PC, di Candio G, Battolla L, et al. Giant pedunculated liposarcomas of the esophagus: literature review and case report. Hepatogastroenterology. 1997;44(14):398–407.

    CAS  PubMed  Google Scholar 

  30. Salis GB, Albertengo JC, Bruno M, Palau G, González Villaveirán R, Lombardo D, et al. Pedunculated liposarcoma of the esophagus. Dis Esophagus. 1998;11(1):68–71.

    CAS  PubMed  Google Scholar 

  31. Temes R, Quinn P, Davis M, Endara S, Follis F, Pett S, et al. Endoscopic resection of esophageal liposarcoma. J Thorac Cardiovasc Surg. 1998;116(2):365–7.

    Article  CAS  PubMed  Google Scholar 

  32. Mandell DL, Brandwein MS, Woo P, Som PM, Biller HF, Urken ML. Upper aerodigestive tract liposarcoma: report on four cases and literature review. Laryngoscope. 1999;109(8):1245–52.

    Article  CAS  PubMed  Google Scholar 

  33. Ruppert-Kohlmayr AJ, Raith J, Friedrich G, Regauer S, Preidler KW, Szolar DH. Giant liposarcoma of the esophagus: radiological findings. J Thorac Imaging. 1999;14(4):316–9.

    Article  CAS  PubMed  Google Scholar 

  34. Beaudoin A, Journet C, Watier A, Mongeau CJ, Chagnon M, Beaudry R. Giant liposarcoma of the esophagus. Can J Gastroenterol. 2002;16(6):377–9.

    Article  PubMed  Google Scholar 

  35. Chung JJ, Kim MJ, Kim JH, Lee JT, Yoo HS, Kim KW. Imaging findings of giant liposarcoma of the esophagus. Yonsei Med J. 2003;44(4):715–8.

    Article  PubMed  Google Scholar 

  36. Bréhant O, Pessaux P, Hennekinne-Mucci S, Barrière E, D’Aubigny N, Aubé C, et al. Giant pedunculated liposarcoma of the esophagus. J Am Coll Surg. 2004;198(2):320–1.

    Article  PubMed  Google Scholar 

  37. Garcia M, Buitrago E, Bejarano PA, Casillas J. Large esophageal liposarcoma: a case report and review of the literature. Arch Pathol Lab Med. 2004;128(8):922–5.

    PubMed  Google Scholar 

  38. Liakakos TD, Troupis TG, Tzathas C, Spirou K, Nikolaou I, Ladas S, et al. Primary liposarcoma of esophagus: a case report. World J Gastroenterol. 2006;12(7):1149–52.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Yang B, Shi PZ, Li X, Xu RJ. Well-differentiated liposarcoma of esophagus. Chin Med J (Engl). 2006;119(5):438–40.

    Google Scholar 

  40. Di Mascio L, Gamble L, Wajed S, Winslet M. Intussuscepting giant liposarcoma of the oesophagus. J Postgrad Med. 2006;52(3):231–2.

    PubMed  Google Scholar 

  41. Maruyama K, Motoyama S, Okuyama M, Sasaki K, Sato Y, Hayashi K, et al. Cervical approach for resection of a pedunculated giant atypical lipomatous tumor of the esophagus. Surg Today. 2007;37(2):173–5.

    Article  PubMed  Google Scholar 

  42. Xu S, Xu Z, Hou Y, Tan Y. Primary pedunculated giant esophageal liposarcoma: case report. Dysphagia. 2008;23(3):327–30.

    Article  PubMed  Google Scholar 

  43. Mica L, Gianom D, Bode B, Jaklin P, Hollinger A. Rare cause of dysphagy: giant polypoid esophageal well-differentiated liposarcoma. Case Rep Gastroenterol. 2007;1(1):7–14.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Will U, Lorenz P, Urban H, Meyer F. Curative endoscopic resection of a huge pedunculated esophageal liposarcoma. Endoscopy. 2007;39 Suppl 1:E15–6.

    Article  PubMed  Google Scholar 

  45. Czekajska-Chehab E, Tomaszewska M, Drop A, Dabrowski A, Skomra D, Orłowski T, et al. Liposarcoma of the esophagus: case report and literature review. Med Sci Monit. 2009;15(7):CS123–7.

    PubMed  Google Scholar 

  46. Jakowski JD, Wakely Jr PE. Rhabdomyomatous well-differentiated liposarcoma arising in giant fibrovascular polyp of the esophagus. Ann Diagn Pathol. 2009;13(4):263–8.

    Article  PubMed  Google Scholar 

  47. Smith MA, Kluck E, Jagannath S, Yang SC. Giant multi-polypoid liposarcoma of the esophagus: an atypical presentation. Ann Thorac Surg. 2010;89(2):610–2.

    Article  PubMed  Google Scholar 

  48. Moretti R, Cimino F, Vacca U, Rubinato L. Giant low-grade liposarcoma of distal esophagus. Eur J Cardiothorac Surg. 2011;39(5):795.

    Article  PubMed  Google Scholar 

  49. Watkin E, Devouassoux-Shisheboran M, Pedeutour F, Lagarde P, Salle M, Ranchère-Vince D, et al. A first reported case of dedifferentiated liposarcoma of the esophagus with molecular diagnosis. J Gastrointest Cancer. 2011;42(1):65–7.

    Article  PubMed  Google Scholar 

  50. Hasanabadi MS, Amiri M, Tajedini A, Yazdi AK, Heidarali M, Amali A, et al. Huge myxoid liposarcoma of the esophagus: a case report. Acta Med Iran. 2011;49(2):118–21.

    PubMed  Google Scholar 

  51. Myung JK, Jeong JB, Han D, Song CS, Moon HJ, Kim YA, et al. Well-differentiated liposarcoma of the oesophagus: clinicopathological, immunohistochemical and array CGH analysis. Pathol Oncol Res. 2011;17(2):415–20.

    Article  PubMed  Google Scholar 

  52. Sui X, Li Y, Zhao H, Wang J. Giant liposarcoma of the esophagus with Li-Fraumeni-like syndrome. Eur J Cardiothorac Surg. 2011;40(5):1253–5.

    PubMed  Google Scholar 

  53. Boni A, Lisovsky M, Dal Cin P, Rosenberg AE, Srivastava A. Atypical lipomatous tumor mimicking giant fibrovascular polyp of the esophagus: report of a case and a critical review of literature. Hum Pathol. 2013;44(6):1165–70.

    Article  PubMed  Google Scholar 

  54. Saleh WN, Aljehani YM, Ahmad MH. Giant pedunculated esophageal liposarcoma associated with Hurthle cell thyroid neoplasia. Saudi Med J. 2013;34(7):750–2.

    PubMed  Google Scholar 

  55. Beylergil V, Simmons MZ, Ulaner G, Jurcic J, Hibshoosh H, Carrasquillo JA. FDG PET/CT findings in a rare case of giant fibrovascular polyp of the esophagus harboring atypical lipomatous tumor/well-differentiated liposarcoma. Clin Nucl Med. 2014;39(3):288–91.

    Article  PubMed  Google Scholar 

  56. Riva G, Sensini M, Corvino A, Vittone F, Garzaro M, Pecorari G. Rare giant pedunculated liposarcoma of the hypopharynx: case report and review of literature. J Gastrointest Cancer. 2015. doi:10.1007/s12029-015-9767-3.

    PubMed  Google Scholar 

  57. Zevallos JP, Shah RP, Baredes S. Giant fibrovascular polyp of the hypopharynx. Laryngoscope. 2005;115:876–8.

    Article  PubMed  Google Scholar 

  58. Hoseok I, Kim JS, Shim YM. Giant fibrovascular polyp of the hypopharynx: surgical treatment with the biapproach. J Korean Med Sci. 2006;21:749–51.

    Article  Google Scholar 

  59. Enzinger FM, Weis SW. Soft tissue tumors. St Louis: Mosby; 1995. p. 431–66.

    Google Scholar 

  60. Fletcher CDM, Sundaram M, Rydholm A, Coindre JM, Singer S. Soft tissue tumours: epidemiology, clinical features, histopathological typing and grading. In: Fletcher CDM, Krishnan Unni K, Mertens F, editors. World Health Organization classification of tumours. Pathology and genetics of tumours of soft tissue and bone. Lyon: IARC Press; 2002. p. 12–8.

    Google Scholar 

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Authors and Affiliations

  1. 1st ENT Division, Surgical Sciences Department, University of Turin, Via Genova 3, 10126, Turin, Italy

    Giuseppe Riva, Matteo Sensini, Andrea Corvino, Massimiliano Garzaro & Giancarlo Pecorari

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  1. Giuseppe Riva
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  2. Matteo Sensini
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  3. Andrea Corvino
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Correspondence to Giuseppe Riva.

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Riva, G., Sensini, M., Corvino, A. et al. Liposarcoma of Hypopharynx and Esophagus: a Unique Entity?. J Gastrointest Canc 47, 135–142 (2016). https://doi.org/10.1007/s12029-016-9808-6

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