Skip to main content

Advertisement

Log in

A Rare Case of a Gastrointestinal Stromal Tumor (GIST) Presenting as a Perforated Meckel’s Diverticulum

  • Case Report
  • Published:
Journal of Gastrointestinal Cancer Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

References

  1. Zani A, Eaton S, Rees CM, Pierro A. Incidentally detected Meckel diverticulum: to resect or not to resect? Ann Surg. 2008;247:276–81. doi:10.1097/SLA.0b013e31815aaaf8.

    Article  PubMed  Google Scholar 

  2. Sagar J, Kumar V, Shah DK. Meckel’s diverticulum: a systematic review. J R Soc Med. 2006;99:501–5.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Thirunavukarasu P, Sathaiah M, Sukumar S, Bartels CJ, Zeh 3rd H, Lee KK, et al. Meckel’s diverticulum-a high-risk region for malignancy in the ileum. Insights from a population-based epidemiological study and implications in surgical management. Ann Surg. 2011;252:223–30. doi:10.1097/SLA.0b013e3181ef488d.

    Article  Google Scholar 

  4. López-Tomassetti Fernández EM, Hernández JR, Jorge VN. Perforated gastrointestinal stromal tumor in Meckel’s diverticulum treated laparoscopically. Asian J Endosc Surg. 2013;6:126–9. doi:10.1111/ases.12016.

    Article  PubMed  Google Scholar 

  5. Szentpáli K, Palotás A, Wolfárd A, Tiszlavicz L, Balogh A. A gastrointestinal stromal tumour presenting in a perforated Meckel’s diverticulum. Can J Surg. 2004;47:70.

    PubMed  PubMed Central  Google Scholar 

  6. Hager M, Maier H, Eberwein M, Klingler P, Kolbitsch C, Tiefenthaler W, et al. Perforated Meckel’s diverticulum presenting as a gastrointestinal stromal tumor: a case report. J Gastrointest Surg. 2005;9:809–11.

    Article  PubMed  Google Scholar 

  7. Dogrul AB, Kilic YA, Onurdag F, Onder S, Tirnaksiz MB, Abbasoglu O. A gastrointestinal stromal tumor in Meckel diverticulum in an 86-year-old patient. Am J Med Sci. 2010;340:156–7. doi:10.1097/MAJ.0b013e3181dfbb94.

    Article  PubMed  Google Scholar 

  8. Caricato M, Mangiameli G, Miccadei F, Bulzomi G, Coppola R. A rare case of complicated Meckel’s diverticulum. Case report and images. Ann Ital Chir. 2010;81:449–51.

    PubMed  Google Scholar 

  9. Chou YH, Tu CC, Huang CC, Hsieh MS. A clinically-occult gastrointestinal stromal tumor in a Meckel’s diverticulum presenting as hollow organ perforation. Chang Gung Med J. 2011;34:56–61.

    PubMed  Google Scholar 

  10. Sozen S, Ömer T (2012) A rare case of perforated Meckel’s diverticulum presenting as a gastrointestinal stromal tumor. Arch Iran Med 15:325-327. doi: 012155/AIM.0016.

  11. Mitura K, Blicharz P, Romańczuk M. Perforated gist of Meckel’s diverticulum. Pol Przeql Chir. 2012;84:258–61. doi:10.2478/v10035-012-0043-y.

    Google Scholar 

  12. Woolf R, Blencowe N, Muhammad K, Paterson D, Pye G. A gastrointestinal stromal tumor presenting incidentally with haemorrhage and perforation associated with a Meckel’s diverticulum: a case report. J Med Case Rep. 2009;23:7423. doi:10.4076/1752-1947-3-7423.

    Article  Google Scholar 

  13. Goyal R, Chaudhary NK. Gastrointestinal stromal tumor of Meckel’s diverticulum causing perforation and peritonitis: a case report. Indian J Surg. 2013;75 Suppl 1:S171–3. doi:10.1007/s12262-012-0556-y.

    Article  Google Scholar 

  14. Mulholland MW, Lillemoe KD, Doherty GM, et al. Greenfield’s Surgery: Scientific Principles and Practice. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2011.

    Google Scholar 

  15. Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2015. CA Cancer J Clin. 2015;65:5–29. doi:10.3322/caac.21254.

    Article  PubMed  Google Scholar 

  16. Bilimoria KY, Bentrem DJ, Wayne JD, Ko CY, Bennett CL, Talamonti MS. Small bowel cancer in the Unites States: changes in epidemiology, treatment, and survival over the last 20 years. Ann Surg. 2009;249:63–71.

    Article  PubMed  Google Scholar 

  17. Miettinen M, Lasota J. Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis. Arch Pathol Lab Med. 2006;130:1466–78.

    CAS  PubMed  Google Scholar 

  18. Ma GL, Murphy JD, Martinez ME, Sicklick JK. Epidemiology of gastrointestinal stromal tumors in the era of histology codes: results of a population-based study. Cancer Epidemiol Biomarkers Prev. 2015;24:298–302. doi:10.1158/1055-9965.

    Article  PubMed  Google Scholar 

  19. Verweij J, Casali PG, Zalcberg J. Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trial. Lancet. 2004;364:1127–34.

    Article  CAS  PubMed  Google Scholar 

  20. Dematteo RP, Ballman KV, Antonescu CR, et al. Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial. Lancet. 2009;373:1097–104. doi:10.1016/S0140-6736(09)60500-6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Dematteo RP, Heinrich MC, El-Rifai WM, Demetri G. Clinical management of gastrointestinal stromal tumors: before and after STI-571. Hum Pathol. 2002;33:466–77.

    Article  CAS  PubMed  Google Scholar 

  22. Bonvalot S, Eldweny H, Péchoux CL, et al. Impact of surgery on advanced gastrointestinal stromal tumors (GIST) in the imatinib era. Ann Surg Oncol. 2006;13:1596–603.

    Article  CAS  PubMed  Google Scholar 

  23. Dematteo RP, Lewis JJ, Leung D, Mudan SS, Woodruff JM, Brennan MF. Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival. Ann Surg. 2000;231:51–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Fiore M, Palassini E, Fumagalli E, et al. Preoperative imatinib mesylate for unresectable or locally advanced primary gastrointestinal stromal tumors (GIST). Eur J Surg Oncol. 2008;35:739–45. doi:10.1016/j.ejso.2008.11.005.

    Article  PubMed  Google Scholar 

  25. Demetri G, Mehren MV, Blanke CD, et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med. 2002;347:472–80.

    Article  CAS  PubMed  Google Scholar 

  26. Antonescu CR, Besmer P, Guo T. Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation. Clin Cancer Res. 2005;11:4182–90.

    Article  CAS  PubMed  Google Scholar 

  27. Demetri GD, Reichardt P, Kang YK, et al. Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet. 2013;381:295–302. doi:10.1016/S0140-6736(12)61857-1.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

The authors would like to acknowledge Dr. Larry S. Lewis, MD as the attending surgeon on this case. We would also like to acknowledge Dr. Jeffrey A Conklin, MD, the pathologist working with this case, for assistance with the acquisition of slides. Finally, Dr. Mark Trottier, PhD, for his assistance with article revision and editing.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Andrea Kay Bouman.

Ethics declarations

Informed Consent

Informed consent was obtained from the individual described in this report.

Conflict of Interest

The authors declare that they have no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Omerza, C.R., Bouman, A.K. & Bulinski, P.P. A Rare Case of a Gastrointestinal Stromal Tumor (GIST) Presenting as a Perforated Meckel’s Diverticulum. J Gastrointest Canc 48, 76–79 (2017). https://doi.org/10.1007/s12029-016-9803-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12029-016-9803-y

Keywords

Navigation