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H. pylori Infection, Inflammation and Gastric Cancer

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Abstract

Introduction

A strong association between chronic infection, inflammation, and cancer has been suggested.

Discussion

Helicobacter pylori, a microaerophilic gram negative bacterium, infects about half the world’s population. It has been defined as a definitive carcinogen in the pathogenesis of gastric cancer. H. pylori evades the host immune responses and persists in the stomach leading to gastritis gastric atrophy and sometimes gastric cancer.

Conclusion

Chronic H. pylori infection causes gastric cancer via two mechanisms: the presence of virulence factors and the induction of chronic inflammation which ultimately leads to neoplastic transformation.

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Authors and Affiliations

  1. Department of Immunology and Molecular Medicine, Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Soura, Srinagar, Jammu and Kashmir, 190011, India

    Qurteeba Qadri, Roohi Rasool & Zafar A. Shah

  2. Department of Gastroenterology, Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Soura, Srinagar, Jammu and Kashmir, 190011, India

    G. M. Gulzar

  3. Department of General Surgery, Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Soura, Srinagar, Jammu and Kashmir, 190011, India

    Sameer Naqash

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  1. Qurteeba Qadri
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Qadri, Q., Rasool, R., Gulzar, G.M. et al. H. pylori Infection, Inflammation and Gastric Cancer. J Gastrointest Canc 45, 126–132 (2014). https://doi.org/10.1007/s12029-014-9583-1

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