Skip to main content
Log in

β-Catenin Pathway in Ulcerative Colitis-Associated Colorectal Cancer and Therapeutic Implication

  • LETTER TO THE EDITOR
  • Published:
Journal of Gastrointestinal Cancer Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. ACS-CS. http://www.cancer.org/docroot/STT/stt_0_2008.asp?sitearea=STT&level=1, 2008.

  2. Jones S, Chen WD, Parmigiani G, Diehl F, Beerenwinkel N, Antal T, et al. Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci U S A. 2009;105:4283–8. doi:10.1073/pnas.0712345105.

    Article  Google Scholar 

  3. Mees ST, Mennigen R, Spieker T, Rijcken E, Senninger N, Haier J, et al. Expression of tight and adherens junction proteins in ulcerative colitis associated colorectal carcinoma: upregulation of claudin-1, claudin-3, claudin-4, and beta-catenin. Int J Colorectal Dis. 2009;24:361–8. doi:10.1007/s00384-009-0653-y.

    Article  PubMed  CAS  Google Scholar 

  4. Itzkowitz SH, Yio X. Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation. Am J Physiol Gastrointest Liver Physiol. 2004;287:G7–17. doi:10.1152/ajpgi.00079.2004.

    Article  PubMed  CAS  Google Scholar 

  5. Bromberg J, Wang TC. Inflammation and cancer: IL-6 and STAT3 complete the link. Cancer Cell. 2009;15:79–80. doi:10.1016/j.ccr.2009.01.009.

    Article  PubMed  CAS  Google Scholar 

  6. Greten FR, Eckmann L, Greten TF, Park JM, Li ZW, Egan LJ, et al. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell. 2004;118:285–96. doi:10.1016/j.cell.2004.07.013.

    Article  PubMed  CAS  Google Scholar 

  7. Burstein E, Fearon ER. Colitis and cancer: a tale of inflammatory cells and their cytokines. J Clin Invest. 2008;118:464–7.

    PubMed  CAS  Google Scholar 

  8. Popivanova BK, Kitamura K, Wu Y, Kondo T, Kagaya T, Kaneko S, et al. Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis. J Clin Invest. 2008;118:560–70.

    PubMed  CAS  Google Scholar 

  9. Arnold CN, Goel A, Niedzwiecki D, Dowell JM, Wasserman L, Compton C, et al. APC promoter hypermethylation contributes to the loss of APC expression in colorectal cancers with allelic loss on 5q. Cancer Biol Ther. 2004;3:960–4.

    Article  PubMed  CAS  Google Scholar 

  10. Kline CL, Olson TL, Irby RB. Src activity alters alpha3 integrin expression in colon tumor cells. Clin Exp Metastasis. 2009;26:77–87. doi:10.1007/s10585-008-9215-x.

    Article  PubMed  CAS  Google Scholar 

  11. Song S, Mazurek N, Liu C, Sun Y, Ding QQ, Liu K, et al. Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3beta activity. Cancer Res. 2009;69:1343–9. doi:10.1158/0008-5472.CAN-08-4153.

    Article  PubMed  CAS  Google Scholar 

  12. Fujise T, Iwakiri R, Kakimoto T, Shiraishi R, Sakata Y, Wu B, et al. Long-term feeding of various fat diets modulates azoxymethane-induced colon carcinogenesis through Wnt/beta-catenin signaling in rats. Am J Physiol Gastrointest Liver Physiol. 2007;292(4):G1150–G6. 292(294):G1150-1156.

    Article  PubMed  CAS  Google Scholar 

  13. Bos CL, Diks SH, Hardwick JC, Walburg KV, Peppelenbosch MP, Richel DJ. Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A. Oncogene. 2006;25:6447–56. doi:10.1038/sj.onc.1209658.

    Article  PubMed  CAS  Google Scholar 

  14. Chen J. Is Src the key to understanding metastasis and developing new treatments for colon cancer? Nat Clin Pract Gastroenterol Hepatol. 2008;5:306–7. doi:10.1038/ncpgasthep1141.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Jiezhong Chen or Xu-Feng Huang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chen, J., Huang, XF. β-Catenin Pathway in Ulcerative Colitis-Associated Colorectal Cancer and Therapeutic Implication. J Gastrointest Canc 40, 64–65 (2009). https://doi.org/10.1007/s12029-009-9070-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12029-009-9070-2

Keywords

Navigation