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Early Derangements in Oxygen and Glucose Metabolism Following Head Injury: The Ischemic Penumbra and Pathophysiological Heterogeneity

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Abstract

Introduction

Conclusive evidence of cerebral ischemia following head injury has been elusive. We aimed to use 15O and 18Fluorodeoxyglucose positron emission tomography (PET) to investigate pathophysiological derangements following head injury.

Results

Eight patients underwent PET within 24 h of injury to map cerebral blood flow (CBF), cerebral oxygen metabolism (CMRO2), oxygen extraction fraction (OEF), and cerebral glucose metabolism (CMRglc). Physiological regions of interest (ROI) were generated for each subject using a range of OEF values from very low (<10), low (10–30), normal range (30–50), high (50–70), and critically high (≥70%). We applied these ROIs to each subject to generate data that would examine the balance between blood flow and metabolism across the injured brain independent of structural injury.

Discussion

Compared to the normal range, brain regions with higher OEF demonstrate a progressive CBF reduction (P < 0.01), CMRO2 increase (P < 0.05), and no change in CMRglc, while regions with lower OEF are associated with reductions in CBF, CMRO2, and CMRglc (P < 0.01). Although all subjects demonstrate a decrease in CBF with increases in OEF > 70%, CMRO2 and CMRglc were generally unchanged. One subject demonstrated a reduction in CBF and small fall in CMRO2 within the high OEF region (>70%), combined with a progressive increase in CMRglc.

Conclusions

The low CBF and maintained CMRO2 in the high OEF ROIs is consistent with classical cerebral ischemia and the presence of an ‘ischemic penumbra’ following early head injury, while the metabolic heterogeneity that we observed suggests significant pathophysiological complexity. Other mechanisms of energy failure are clearly important and further study is required to delineate the processes involved.

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Authors and Affiliations

  1. The Division of Anaesthesia, Addenbrooke’s Hospital, University of Cambridge, Box 93, Cambridge, CB2 2QQ, UK

    M. Giulia Abate, Monica Trivedi, Doris A. Chatfield, David K. Menon & Jonathan P. Coles

  2. The Wolfson Brain Imaging Centre, Addenbrooke’s Hospital, University of Cambridge, Box 65, Cambridge, CB2 2QQ, UK

    M. Giulia Abate, Monica Trivedi, Tim D. Fryer, Doris A. Chatfield, Guy B. Williams, Franklin Aigbirhio, T. Adrian Carpenter, John D. Pickard, David K. Menon & Jonathan P. Coles

  3. College of Medicine, HS Gerardo, The University of Milano – Bicocca, 20052, Monza, Milano, Italy

    M. Giulia Abate

  4. Department of Neurosurgery, Addenbrooke’s Hospital, University of Cambridge, Box 167, Cambridge, CB2 2QQ, UK

    Piotr Smielewski & John D. Pickard

Authors
  1. M. Giulia Abate
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  2. Monica Trivedi
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  3. Tim D. Fryer
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  4. Piotr Smielewski
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  5. Doris A. Chatfield
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  6. Guy B. Williams
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  7. Franklin Aigbirhio
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  8. T. Adrian Carpenter
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  9. John D. Pickard
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  10. David K. Menon
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  11. Jonathan P. Coles
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Correspondence to Jonathan P. Coles.

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Abate, M.G., Trivedi, M., Fryer, T.D. et al. Early Derangements in Oxygen and Glucose Metabolism Following Head Injury: The Ischemic Penumbra and Pathophysiological Heterogeneity. Neurocrit Care 9, 319–325 (2008). https://doi.org/10.1007/s12028-008-9119-2

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  • DOI: https://doi.org/10.1007/s12028-008-9119-2

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