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Emerging role of adipokines in systemic lupus erythematosus

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Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by multisystem organ involvement and unclear pathogenesis. Several adipokines synthesized in the adipose tissue, including leptin, adiponectin, resistin, and chemerin, have been explored in autoimmune rheumatic diseases, especially SLE, and results suggest that these mediators may be implicated in the pathogenesis of SLE. However, the current results are controversial. In this review, we will briefly discuss the expression and possible pathogenic role of several important adipokines, including leptin, adiponectin, resistin, and chemerin in SLE.

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Acknowledgments

This work was supported by Grants from the National Natural Science Foundation of China (81573222, 81473058).

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    1. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People’s Republic of China

      Hong-Miao Li, Tian-Ping Zhang, Rui-Xue Leng, Dong-Qing Ye & Hai-Feng Pan

    2. Anhui Provincial Laboratory of Population Health and Major Disease Screening and Diagnosis, Hefei, People’s Republic of China

      Hong-Miao Li, Tian-Ping Zhang, Rui-Xue Leng, Dong-Qing Ye & Hai-Feng Pan

    3. Department of Rheumatology, Anhui Provincial Hospital, Hefei, People’s Republic of China

      Xiang-Pei Li & Xiao-Mei Li

    4. Graduate School, Wannan Medical College, West of Wenchang Road, University Park, Wuhu, 241002, Anhui, People’s Republic of China

      Hai-Rong Liu

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    Li, HM., Zhang, TP., Leng, RX. et al. Emerging role of adipokines in systemic lupus erythematosus. Immunol Res 64, 820–830 (2016). https://doi.org/10.1007/s12026-016-8808-8

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