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The Genotype and Phenotype (GaP) registry: a living biobank for the analysis of quantitative traits

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Abstract

We describe the development of the Genotype and Phenotype (GaP) Registry, a living biobank of normal volunteers who are genotyped for genetic markers related to human disease. Participants in the GaP can be recalled for hypothesis driven study of disease associated genetic variants. The GaP has facilitated functional studies of several autoimmune disease associated loci including Csk, Blk, PDRM1 (Blimp-1) and PTPN22. It is likely that expansion of such living biobank registries will play an important role in studying and understanding the function of disease associated alleles in complex disease.

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Authors and Affiliations

  1. Robert S. Boas Center for Genomics and Human Genetics, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA

    Peter K. Gregersen, Gila Klein, Mary Keogh, Marlena Kern, Margaret DeFranco & Kim R. Simpfendorfer

  2. Center for Autoimmune and Musculoskeletal Disease, The Feinstein Institute for Medical Research, Manhasset, NY, USA

    Sun Jung Kim & Betty Diamond

Authors
  1. Peter K. Gregersen
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  2. Gila Klein
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  3. Mary Keogh
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  4. Marlena Kern
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  5. Margaret DeFranco
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  6. Kim R. Simpfendorfer
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  7. Sun Jung Kim
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  8. Betty Diamond
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Correspondence to Peter K. Gregersen.

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Gregersen, P.K., Klein, G., Keogh, M. et al. The Genotype and Phenotype (GaP) registry: a living biobank for the analysis of quantitative traits. Immunol Res 63, 107–112 (2015). https://doi.org/10.1007/s12026-015-8711-8

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  • DOI: https://doi.org/10.1007/s12026-015-8711-8

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