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The immune system and head and neck squamous cell carcinoma: from carcinogenesis to new therapeutic opportunities

  • Immunology & Microbiology in Miami
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Abstract

Head and neck squamous cell carcinomas (HNSCCs) exhibit complex interactions with the host immune system that may simultaneously explain resistance to various therapeutic modalities and that may also provide opportunities for therapeutic intervention. Discoveries in immunologic research over the last decade have led to an increased understanding of these interactions as well as the development of a multitude of investigational immunotherapies. Here, we describe the interaction between HNSCC and the immune system, including a discussion of immune cells involved with tumor carcinogenesis and the role of immune-modulating factors derived from tumors. We also describe the current immunotherapeutic approaches being investigated for HNSCC, including a discussion of the successes and limitations. With this review, we hope to present HNSCC as a model to guide future research in cancer immunology.

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Acknowledgments

This work was supported by the Flight Attendant Medical Research Institute (FAMRI)’s young investigator award, by the Bankhead Coley Cancer Research Program Grant 2BF0650904.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, University of Miami Miller School of Medicine, RMSB 3075, 1600 NW 10th Avenue, Miami, FL, 33136, USA

    Paolo Serafini

  2. Division of Head and Neck Surgery, Department of Otolaryngology, University of Miami Miller School of Medicine, 1475 NW 12th Avenue, 3rd Flr, Suite 3550, Miami, FL, 33136, USA

    Donald T. Weed

  3. University of Miami Miller School of Medicine, 1475 NW 12th Avenue, 3rd Flr, Suite 3550, Miami, FL, 33136, USA

    Monika E. Freiser

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  1. Monika E. Freiser
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  2. Paolo Serafini
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  3. Donald T. Weed
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Correspondence to Paolo Serafini or Donald T. Weed.

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Freiser, M.E., Serafini, P. & Weed, D.T. The immune system and head and neck squamous cell carcinoma: from carcinogenesis to new therapeutic opportunities. Immunol Res 57, 52–69 (2013). https://doi.org/10.1007/s12026-013-8462-3

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  • DOI: https://doi.org/10.1007/s12026-013-8462-3

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