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Myeloid-derived suppressor cells in transplantation and cancer

  • Immunology at Mount Sinai
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Abstract

Myeloid-derived suppressor cells (MDSC) are myeloid cells that suppress the immune response, a definition that reflects both their origin and their function. As negative regulators of the immune response, MDSC represent a novel therapeutic approach for manipulating the immune system toward tolerance or immunity. MDSC are present in cancer patients and tumor-bearing mice and are in part responsible for the inhibition of the cell-mediated immune response against the tumor. Our laboratories investigate the immunologic mechanisms of tumor acceptance mediated by MDSC, which can be exploited to prevent allograft rejection in transplantation. A better understanding of MDSC biology will open new avenues for therapeutic intervention, either by inhibiting their function (i.e. in cancer patients), or by enhancing their suppressive effects and promoting their expansion (i.e. in organ transplantation and alloimmune responses). In this review, we summarize some of the critical aspects of the immunoregulatory function of MDSC in cancer and transplantation and discuss their potential clinical applications.

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Acknowledgments

This work was supported by NIH grants to S.H.C. J.C.O. is a recipient of American Society of Transplantation/Pfizer basic sciences faculty development grant. We like to thank Dr. Ge Ma's helpful discussion and editing.

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Authors and Affiliations

  1. Department of Nephrology, Mount Sinai School of Medicine, New York, NY, USA

    Jordi C. Ochando

  2. Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY, USA

    Shu Hsia Chen

  3. Immunology Institute, Mount Sinai School of Medicine, New York, NY, USA

    Jordi C. Ochando & Shu Hsia Chen

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  1. Jordi C. Ochando
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  2. Shu Hsia Chen
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Correspondence to Jordi C. Ochando.

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Ochando, J.C., Chen, S.H. Myeloid-derived suppressor cells in transplantation and cancer. Immunol Res 54, 275–285 (2012). https://doi.org/10.1007/s12026-012-8335-1

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