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Regulation of the immune response by soybean isoflavones

  • Immunology at Mount Sinai
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Abstract

Soybeans are rich in immuno-modulatory isoflavones such as genistein, daidzein, and glycitein. These isoflavones are well-known antioxidants, chemopreventive and anti-inflammatory agents. Several epidemiological studies suggest that consumption of traditional soy food containing isoflavones is associated with reduced prevalence of chronic health disorders. Isoflavones are considered to be phytoestrogens because of their ability to bind to estrogen receptors. The literature is extensive on the chemistry, bio-availability, and bio-activity of isoflavones. However, their effects on immune response are yet to be fully understood, but are beginning to be appreciated. We review the role of isoflavones in regulation of the immune response and their potential clinical applications in immune-dysfunction. Special emphasis will be made regarding in vivo studies including humans and animal model systems.

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Acknowledgments

This work is funded by the Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY.

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  1. Division of Pediatric Allergy and Immunology, Department of Pediatrics, Anbg 17-40G, Mount Sinai School of Medicine, The Jaffe Food Allergy Institute, One Gustave L Levy Place, New York, NY, 10029, USA

    Madhan Masilamani, John Wei & Hugh A. Sampson

  2. Mount Sinai School of Medicine, Immunology Institute, New York, NY, USA

    Madhan Masilamani & Hugh A. Sampson

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  1. Madhan Masilamani
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Correspondence to Madhan Masilamani.

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Masilamani, M., Wei, J. & Sampson, H.A. Regulation of the immune response by soybean isoflavones. Immunol Res 54, 95–110 (2012). https://doi.org/10.1007/s12026-012-8331-5

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