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Mouse models for Chikungunya virus: deciphering immune mechanisms responsible for disease and pathology

  • Singapore Immunology Network
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Abstract

Chikungunya virus (CHIKV), an alphavirus, has been responsible for large epidemic outbreaks with serious economic and social impact during the last 6 years. Transmitted by Aedes mosquitoes, it causes Chikungunya fever, an acute illness in patients with a stooped posture often associated with chronic and incapacitating arthralgia. The unprecedented re-emergence has stimulated renewed interest in CHIKV. This review discusses the advantages and disadvantages of different animal models for CHIKV infections and their importance to study the role of the immune system in different pathologies caused by CHIKV. We also reveal how such studies still present a difficult challenge, but are indispensible for mechanistic studies to further understand the pathophysiology of CHIKV infections.

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Acknowledgments

We wish to thank Nicholas K.W. Yeo for helpful discussions and suggestions. We are also grateful to Laurent Renia for critical reading of this manuscript. This work is supported in part by the intramural research funds by the Biomedical Research Council (BMRC), Agency for Science, Technology and Research (A*STAR) and also A*STAR’s Joint Council Office (JCO) Research Grant (grant number: CCOGA02_008_2008). T. Teo is funded by a post-graduate scholarship by the A*STAR Graduate Academy (AGA), and F. Lum is funded by a post-graduate research scholarship by the National University of Singapore (NUS).

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Authors and Affiliations

  1. Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, #04 Immunos, Biopolis, Singapore, 138648, Singapore

    Teck-Hui Teo, Fok-Moon Lum, Wendy W. L. Lee & Lisa F. P. Ng

  2. NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, 117456, Singapore

    Teck-Hui Teo

  3. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore

    Fok-Moon Lum & Lisa F. P. Ng

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  1. Teck-Hui Teo
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  2. Fok-Moon Lum
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  3. Wendy W. L. Lee
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  4. Lisa F. P. Ng
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Correspondence to Lisa F. P. Ng.

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Teck-Hui Teo and Fok-Moon Lum contributed equally to this work.

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Teo, TH., Lum, FM., Lee, W.W.L. et al. Mouse models for Chikungunya virus: deciphering immune mechanisms responsible for disease and pathology. Immunol Res 53, 136–147 (2012). https://doi.org/10.1007/s12026-012-8266-x

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