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Transcriptional regulation by STAT6

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Abstract

Signal transducer and activator of transcription (STAT) proteins are critical mediators of cytokine signaling. Among the seven STAT proteins, STAT6 is activated by IL-4 and IL-13 and plays a predominant role in the immune system. However, there is increasing evidence that STAT6 may function in other tissues and organ systems. IL-4, IL-13, and STAT6 promote humoral immunity, clearance of helminthic parasites as well as the pathogenesis of allergic disorders like asthma, food allergies, and atopic dermatitis. In this review, we will describe our current understanding of the biological functions of STAT6 and summarize recent advances in understanding the molecular mechanisms by which STAT6 regulates transcription.

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Acknowledgments

We have made an attempt to be comprehensive in citing all the studies that involve the transcription function of STAT6; however, we apologize if we have inadvertently omitted citing the work of any colleagues. This review was supported by PHS grants from the NIH, AI070448 and AI057459 to MHK and HL093105 to SG.

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  1. HB Wells Center of Pediatric Research, Department of Pediatrics, Microbiology and Immunology, Indiana University School of Medicine, 1044 W Walnut Street, Indianapolis, IN, 46202, USA

    Shreevrat Goenka & Mark H. Kaplan

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  1. Shreevrat Goenka
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  2. Mark H. Kaplan
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Correspondence to Shreevrat Goenka.

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Goenka, S., Kaplan, M.H. Transcriptional regulation by STAT6. Immunol Res 50, 87–96 (2011). https://doi.org/10.1007/s12026-011-8205-2

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