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On the logic of restrictive recognition of peptide by the T-cell antigen receptor

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Abstract

This essay provides an analysis of the inadequacy of the current view of restrictive recognition of peptide by the T-cell antigen receptor. A competing model is developed, and the experimental evidence for the prevailing model is reinterpreted in the new framework. The goal is to contrast the two models with respect to their consistency, coverage of the data, explanatory power, and predictability.

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Acknowledgments

This work was supported by a grant (RR07716) from the National Center For Research Resources (NCRR), a component of the National Institutes of Health (NIH) and its contents are solely the responsibility of the author and does not represent the official view of NCRR or NIH.

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The author has no financial conflict of interest.

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  1. Conceptual Immunology Group, The Salk Institute For Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Melvin Cohn

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Cohn, M. On the logic of restrictive recognition of peptide by the T-cell antigen receptor. Immunol Res 50, 49–68 (2011). https://doi.org/10.1007/s12026-010-8173-y

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