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Synchronous and Metastatic Papillary and Follicular Thyroid Carcinomas with Unique Molecular Signatures

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Abstract

Despite the relatively high prevalence of thyroid cancer, the occurrence of multiple synchronous, distinct subtypes of primary thyroid carcinoma is uncommon. The incidental finding of papillary thyroid microcarcinoma in a gland with a biologically relevant follicular or medullary carcinoma is more frequent than the synchronous occurrence of multiple clinically significant carcinomas. We report a case of synchronous papillary and follicular thyroid carcinomas metastatic to lymph node and bone, respectively. Next generation sequencing showed BRAF V600E mutation in the primary papillary carcinoma and NRAS Q61R mutation in the primary follicular carcinoma and bony metastasis. To our knowledge, this is the first reported case of synchronous and metastatic primary papillary and follicular carcinomas, and the first report of synchronous BRAF V600E mutated papillary and NRAS mutated follicular carcinoma.

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Authors and Affiliations

  1. Department of Pathology, The University of Chicago Medical Center, 5841 South Maryland Ave, Chicago, IL, 60637, USA

    Vincent Cracolici, Mir Alikhan, Lauren E. Rosen & Nicole A. Cipriani

  2. Division of Molecular Pathology, Department of Pathology, The University of Chicago Medical Center, 5841 South Maryland Ave, Chicago, IL, 60637, USA

    Ibro Mujacic, Sabah Kadri, Nifang Niu & Jeremy P. Segal

  3. Section of Endocrinology, Department of Medicine, The University of Chicago Medical Center, 5841 South Maryland Ave, Chicago, IL, 60637, USA

    David H. Sarne

  4. Department of Pathology, St. Mary’s Hospital, 700 South Park St, Madison, WI, 53715, USA

    Adam Morgan & Samy Desouky

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  1. Vincent Cracolici
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  2. Ibro Mujacic
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  3. Sabah Kadri
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  4. Mir Alikhan
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  5. Nifang Niu
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  6. Jeremy P. Segal
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  7. Lauren E. Rosen
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  11. Nicole A. Cipriani
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Correspondence to Vincent Cracolici.

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For this type of study, formal consent is not required. This article does not contain any studies with human participants or animals performed by any of the authors.

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Cracolici, V., Mujacic, I., Kadri, S. et al. Synchronous and Metastatic Papillary and Follicular Thyroid Carcinomas with Unique Molecular Signatures. Endocr Pathol 29, 9–14 (2018). https://doi.org/10.1007/s12022-017-9491-6

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  • DOI: https://doi.org/10.1007/s12022-017-9491-6

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