Skip to main content
Log in

Malignant Thyroid Teratoma: Report of an Aggressive Tumor in a 64-Year-Old Man

  • Published:
Endocrine Pathology Aims and scope Submit manuscript

Abstract

Malignant teratoma of the thyroid is a rare and aggressive tumor, frequent in children than in adults. Histologically, thyroid teratomas usually show a predominance of a neuroectodermal component. Mature cartilage and bone may be present. We present the case of primary malignant teratoma of the thyroid in a 64-year-old man. Histologically, the tumor displayed a predominant neuroectodermal component. The diagnosis was confirmed by immunohistochemistry. The patient underwent a radical thyroidectomy with central neck dissection as primary treatment and radioiodine treatment afterwards. The patient had local and distant recurrence. A second surgery was performed with poor results and the patient died 3 months afterwards.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Djalilian HR, Linzie B, Maisel RH. Malignant teratoma of the thyroid: review of literature and report of a case. Am J Otolaryngol. 2000;21:112–5

    Article  PubMed  CAS  Google Scholar 

  2. Akoojee SB. A case of cervical teratoma arising in the thyroid gland and causing obstructive respiratory symptoms in a neonate is described. S Afr Med J 1980;57:93–4

    PubMed  CAS  Google Scholar 

  3. Retief PJ. Cervical teratoma: is it rare? S Afr J Surg 1966;4:181–5.

    Google Scholar 

  4. Chen JS, Lai GM, Hsueh S. Malignant thyroid teratoma of an adult: a long-term survival after chemotherapy. Am J Clin Oncol 1998;21:212–4

    Article  PubMed  CAS  Google Scholar 

  5. Saphir O. Teratoma of the neck. Am J Surg 1929; 5: 313–21

    CAS  Google Scholar 

  6. Bale GF. Teratoma of the neck in the region of the thyroid gland: a review of the literature and report of four cases. Am J Pathol 1950;26:565–79

    PubMed  CAS  Google Scholar 

  7. McGoon DC. Teratomas of the neck. Surg Clin North Am 1952;32:1389–95

    Google Scholar 

  8. Carter FB. A case of teratoma of the neck. Lancet 1903;2:1499

    Article  Google Scholar 

  9. Rosai J, Carcangiu ML, DeLellis RA. Tumors of the thyroid gland. In: Rosai J, Sobin LH (eds) Atlas of tumor pathology. 3rd edition. Washington, DC: Armed Forces Institute of Pathology, 1992;280–2

  10. Tsang RW, Brierley JD, Asa SL, Sturgeon JF. Malignant teratoma of the thyroid: aggressive chemoradiation therapy is required after surgery. Thyroid 2003;13:401–4

    Article  PubMed  Google Scholar 

  11. Thompson DR, Rosai J, Heffess CS. Primary thyroid teratomas. Cancer 2000;88:1149–58

    Article  PubMed  CAS  Google Scholar 

  12. Kimler SC, Muth WF. Primary malignant teratoma of the thyroid: case report and literature review of cervical teratomas in adults. Cancer 1978;42:311–7

    Article  PubMed  CAS  Google Scholar 

  13. Cudennec YF, Trannoy P, Briche T, Meyran M, Roguet E, Beautru R et al. Teratomes thyroidiens de l’adulte. Rev Laryngol Otol Rhinol (Bord) 1992;113:213–5

    CAS  Google Scholar 

  14. Asl C, Laeng H, Cerny T, Kinser JA, Rösler H, Häusler R. Primary cervical malignant teratoma with a rib metastasis in an adult: Five-year survival after surgery and chemotherapy. Ann Oncol 1998;9:1015–22

    Article  Google Scholar 

  15. Ueno NT, Amato RJ, Ro JJ, Weber RS. Primary malignant teratoma of the thyroid gland: report and discussion of two cases. Head Neck 1988;20:649–53

    Article  Google Scholar 

  16. Kim E, Bae TS, Kwon Y, Kim TH, Chung KW, Kim SW, Ro J, Lee ES. Primary Malignant Teratoma with a Primitive heuroectodermal Tumor Component in Thyroid Gland: A Case Report. J Korean Med Sci 2007;22:568–71

    Article  PubMed  Google Scholar 

  17. Kemp DR. Teratoma of the neck in the adult. Report of a case and review of the literature. Aust N Z J Surg 1967;36:323–7

    Article  PubMed  CAS  Google Scholar 

  18. Jayaram G, Cheah PL, Yip CH. Malignant teratoma of the thyroid with predominantly neuroepithelial differentiation: fine needle aspiration cytologic, histologic and immunocytochemical features of a case. Acta Cytol 2000;44:375–9

    Article  PubMed  CAS  Google Scholar 

  19. Craver RD, Lipscomb JT, Suskind D, Velez MC. Malignant teratoma of the thyroid with primitive neuroepithelial and mesenchymal sarcomatous components. Ann Diagn Pathol 2001;5:285–92

    Article  PubMed  CAS  Google Scholar 

  20. Siironen P, Hagström J, Mäenpää HO, Louhimo J, Heikkilä A, Heiskanen I, Arola J, Haglund C. Anaplastic and poorly differentiated thyroid carcinoma: therapeutic strategies and treatment outcome of 52 consecutive patients. Oncology. 2010;79:400–8

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to R. Vilallonga.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vilallonga, R., Zafon, C., Ruiz-Marcellan, C. et al. Malignant Thyroid Teratoma: Report of an Aggressive Tumor in a 64-Year-Old Man. Endocr Pathol 24, 132–135 (2013). https://doi.org/10.1007/s12022-013-9250-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12022-013-9250-2

Keywords

Navigation