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Predominant Brenner Tumor Combined with Struma Ovarii Containing a Papillary Microcarcinoma Associated with Benign Peritoneal Strumosis: Report of a Case and Histologic Features

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Abstract

Brenner tumor and struma ovarii, two uncommon ovarian tumors arising alone or together with dermoid cysts or adenomas, are both rare entities. Both tumors rarely become malignant and rarely metastasize. Few published reports describe coexisting Brenner tumor and malignant struma ovarii. Patients in whom these malignancies coexist only occasionally have peritoneal spreading, strumosis, or a history of thyrotoxicosis. The patient we describe, a 74-year-old woman, presented with a 2 months’ history of lower abdominal pain and episodic intestinal subocclusion due to a complex pelvic mass. The mass consisted predominantly of a Brenner tumor associated with struma ovarii containing a single small island of thyroid tissue that had undergone malignant transformation into a well-differentiated papillary carcinoma and also normal thyroid tissue that had spread to the peritoneum. The patient underwent radical surgical treatment and after 7 years follow-up is disease free.

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Acknowledgments

The authors thank the Azienda Policlinico Umberto I and the “Eleonora Lorillard Spencer Cenci Foundation” for their technical and scientific support.

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Authors and Affiliations

  1. Department of Surgery “P. Valdoni”, University of Rome “La Sapienza”, Via Lancisi, 2, 00155, Rome, Italy

    Simone Sibio, Paolo Sammartino, Fabio Accarpio, Daniele Biacchi, Giuliana Caprio, Anna Maria Baccheschi, Tommaso Cornali & Angelo Di Giorgio

  2. Department of Experimental Medicine and Pathology, University of Rome “La Sapienza”, Rome, Italy

    Francesco Borrini

  3. Department of Radiological Sciences, University of Rome “La Sapienza”, Rome, Italy

    Franco Iafrate

  4. Eleonora Lorillard Spencer Cenci Foundation–Rome, Via Lancisi, 2, 00155, Rome, Italy

    Simone Sibio, Paolo Sammartino, Fabio Accarpio, Daniele Biacchi & Angelo Di Giorgio

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  1. Simone Sibio
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  2. Francesco Borrini
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  3. Paolo Sammartino
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  4. Fabio Accarpio
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  5. Daniele Biacchi
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  6. Giuliana Caprio
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  7. Franco Iafrate
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  8. Anna Maria Baccheschi
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  9. Tommaso Cornali
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  10. Angelo Di Giorgio
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Correspondence to Simone Sibio.

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Sibio, S., Borrini, F., Sammartino, P. et al. Predominant Brenner Tumor Combined with Struma Ovarii Containing a Papillary Microcarcinoma Associated with Benign Peritoneal Strumosis: Report of a Case and Histologic Features. Endocr Pathol 21, 199–203 (2010). https://doi.org/10.1007/s12022-010-9123-x

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  • DOI: https://doi.org/10.1007/s12022-010-9123-x

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